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EC number: 205-532-9 | CAS number: 142-29-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restriction;
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute, Subacute and Subchronic Inhalation Toxicity of Cyclopentene
- Author:
- Kimmerle G., Thyssen J.
- Year:
- 1 975
- Bibliographic source:
- Int. Arch. Arbeitsmed. 34, 177-184
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 4 groups of rats (10/sex/dose) were exposed to cyclopentene for 12 weeks.
Laboratroy examinations of blood and urine were carried out. At the end of the exposure period all animals were sacrificed and the internal organs were macroscopically and histologically examined. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclopentene
- EC Number:
- 205-532-9
- EC Name:
- Cyclopentene
- Cas Number:
- 142-29-0
- Molecular formula:
- C5H8
- IUPAC Name:
- cyclopentene
- Details on test material:
- Analytical purity: 99.8 % (technical)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 140-150 g
- Housing: housed in groups of 5 in cages
- Diet (e.g. ad libitum): ad libitum (Altromin standard diet)
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C +/- 2°C
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Remarks:
- presumably whole body application
- Duration of treatment / exposure:
- 12 weeks
- Frequency of treatment:
- 6 hours/day for 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.3, 0.9, 3.2 mg/l (vapour)
Basis:
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: daily
BODY WEIGHT: Yes
- Time schedule for examinations: weekly
HAEMATOLOGY: Yes
- Time schedule for collection of blood: one day before the end of the inhaltation test
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: one day before the end of the inhalation test
- How many animals: all
- Parameters checked: SGPT, SGOT, AP, bilirubin, urea, creatinine, glucose
URINALYSIS: Yes
- Time schedule for collection of urine: one day before the end of the inhalation test
- Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
heart, lungs, liver, spleen, kidneys, adrenals, thyroid, thymus and gonads
HISTOPATHOLOGY: Yes
heart, lungs, liver, spleen, kidneys, adrenals, thyroid, thymus and gonads ,prostata, lymph nodes, brain, eyes aorta, thigh-muscle and sternal bone
Results and discussion
Results of examinations
- Details on results:
- CLINICAL SIGNS AND MORTALITY
no noticeable changes in appearance and behaviour.
BODY WEIGHT AND WEIGHT GAIN
no noticeable changes in body weight
(Body weight gain (in g) at 12 weeks: males - 106 (0.3 mg/ml), 93 (0.9 mg/ml), 93 (3.2 mg/ml) vs. 97 in the control group; females - 26 (0.3 mg/ml), 27 (0.9 mg/ml), 23 (3.2 mg/ml) vs. 25 in the control group)
HAEMATOLOGY/CLINICAL CHEMISTRY
The haematological values and serum-enzyme activities (SGOT, SGPT, P .P) as well as the serum concentrations of urea, creatinine ,
bilirubin and glucose were within the physiological range and
URINANALYSIS
There was no significant change in the composition of the urine .
ORGAN WEIGHTS
None of the organ weights showed statistically significant differences among groups
GROSS PATHOLOGY / HISTOPATHOLOGY: NON-NEOPLASTIC
No histopathological changes were seen which could be attributed to the inhalation of cyclopentene .
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- > 3.2 other: mg/l
- Sex:
- male/female
- Dose descriptor:
- LOAEL
- Effect level:
- > 3.2 other: mg/l
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Results of haemotological examinations
concentrationmg/l | haemoglobing/100ml | RBC10^6/mm³ | Thrombocytes 10^3/mm³ | PVC % | Leucocytes | |||||
Total 10^3/mm³ | Neutro-phils % | Baso-phils% | Eosino-phils% | Lympho-cytes% | Mono-cytes% | |||||
Males | ||||||||||
0 | 14.6 | 8.43 | 995 | 49 | 7.6 | 17 | 1 | 0 | 8 | 0 |
0.3 | 14.4 | 8.45 | 1016 | 48 | 8.2 | 14 | 2 | 0 | 84 | 0 |
0.9 | 14.9 | 8.30 | 1003 | 50 | 5.8 | 18 | 1 | 0 | 81 | 0 |
3.2 | 14.4 | 34 | 980 | 48 | 79 | 16 | 1 | 0 | 83 | 0 |
Females | ||||||||||
0 | 14.0 | 7.78 | 1063 | 60 | 5.5 | 17 | 1 | 0 | 82 | 0 |
0.3 | 14.3 | 7.93 | 1095 | 61 | 5.1 | 16 | 2 | 0 | 82 | 0 |
0.9 | 14.1 | 8.02 | 1066 | 58 | 5.8 | 15 | 2 | 0 | 83 | 0 |
3.2 | 15.0 | 8.51 | 1118 | 58 | 6.1 | 19 | 1 | 0 | 80 | 0 |
means of groups of 10 rats
Results of clinical chemistry examinations
concentrationmg/l | SGOT mU/ml | SGPTmU/ml | APmU/ml | Ureamg/100ml | Creatinine mg/100 ml | Glucose mg/100 ml | Bilirubin mg/100 ml | |||
Males | ||||||||||
0 | 30.7 | 18.1 | 22.6 | 55.0 | 0.88 | 86.5 | 0.18 | |||
0.3 | 33.6 | 21.1 | 239 | 56.1 | 0.95 | 86.6 | 0.10 | |||
0.9 | 28.5 | 17.0 | 212 | 58.1 | 0.85 | 85.0 | 0.10 | |||
3.2 | 28.1 | 18.5 | 218 | 51.5 | 0.90 | 89.6 | 0.14 | |||
Females | ||||||||||
0 | 33.8 | 15.8 | 156 | 51.9 | 0.92 | 87.1 | 0.15 | |||
0.3 | 33.6 | 15.5 | 146 | 52.1 | 0.93 | 88.2 | 0.12 | |||
0.9 | 33.0 | 15.9 | 149 | 48.2 | 0.94 | 85.2 | 0.16 | |||
3.2 | 33.7 | 15.6 | 153 | 48.9 | 0.90 | 89.2 | 0.17 | |||
means of groups of 10 rats
Absolute and relative organ weights
Sex andconcentration (mg/l) | Organ weights | Terminal body weight | |||||||||
Thyroid | Thymus | Heart | Lung | Liver | Spleen | Kidneys | Adrenals | Gonads | |||
Absolut organ weight (mg) | |||||||||||
Males | |||||||||||
0 | 10.1 | 140 | 718 | 1027 | 7565 | 393 | 1733 | 30.0 | 2886 | 252 | |
0.3 | 10.2 | 151 | 723 | 1051 | 8097 | 388 | 1810 | 29.6 | 2821 | 261 | |
0.9 | 10.7 | 145 | 705 | 1046 | 7128 | 386 | 1659 | 27.8 | 2986 | 213 | |
3.2 | 10.7 | 155 | 721 | 1026 | 7630 | 382 | 1794 | 30.1 | 2869 | 244 | |
Females | |||||||||||
0 | 9.0 | 133 | 518 | 847 | 4974 | 292 | 1407 | 37.7 | 42.9 | 167 | |
0.3 | 9.1 | 150 | 535 | 881 | 4907 | 305 | 1418 | 35.8 | 44.5 | 168 | |
0.9 | 9.3 | 151 | 542 | 831 | 5105 | 290 | 1407 | 36.3 | 42.9 | 169 | |
3.2 | 9.4 | 142 | 515 | 851 | 4886 | 291 | 1386 | 36.4 | 41.0 | 701 | |
Relative organ weight (mg/100 g bw) | |||||||||||
Males | |||||||||||
0 | 4.0 | 55 | 285 | 409 | 3003 | 157 | 689 | 11.9 | 1167 | ||
0.3 | 3.9 | 58 | 278 | 403 | 3095 | 149 | 693 | 11.3 | 1061 | ||
0.9 | 4.3 | 58 | 284 | 423 | 2970 | 155 | 666 | 11.2 | 1205 | ||
3.2 | 4.3 | 63 | 296 | 422 | 3121 | 157 | 717 | 12.3 | 1181 | ||
Females | |||||||||||
0 | 5.4 | 80 | 310 | 488 | 2970 | 175 | 857 | 22.6 | 25.7 | ||
0.3 | 5.4 | 89 | 319 | 527 | 2925 | 182 | 841 | 21.3 | 26.5 | ||
0.9 | 5.5 | 89 | 321 | 493 | 3027 | 172 | 835 | 21.5 | 25.4 | ||
3.2 | 5.5 | 88 | 320 | 530 | 2981 | 180 | 832 | 22.7 | 25.8 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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