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Diss Factsheets
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EC number: 207-924-5 | CAS number: 501-52-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice
- Author:
- E. W. Schafer, Jr. and W. A. Bowles, Jr.
- Year:
- 1 985
- Bibliographic source:
- Arch. Environ. Contain. Toxicol. 14, 111-129 (1985)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of 3-phenylpropanoic acid in mice
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 3-phenylpropionic acid
- EC Number:
- 207-924-5
- EC Name:
- 3-phenylpropionic acid
- Cas Number:
- 501-52-0
- Molecular formula:
- C9H10O2
- IUPAC Name:
- 3-phenylpropanoic acid
- Details on test material:
- SMILES:OC(=O)CCc1ccccc1
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 3-Phenylpropionic acid
- Molecular formula (if other than submission substance): C9H10O2
- Molecular weight (if other than submission substance): 150.176 g/mole
- Substance type: Organic
Test animals
- Species:
- mouse
- Strain:
- other: Deer
- Remarks:
- Peromyscus maniculatus
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- - Source: No data available
- Age at study initiation: No data available
- Weight at study initiation: 20 gm
- Fasting period before study: No data available
- Housing: Animlas were individually caged.
- Diet (e.g. ad libitum): An alternate less preferred food (laboratory rodent pellets available ad lib.
- Water (e.g. ad libitum): water was available ad lib.
- Acclimation period: No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: water, corn oil, or 1.0% carbopol as carriers
- Details on oral exposure:
- Using this single animal per level method, each succeeding treatment was 50% higher than the preceding level and continued until mortality occurred
- Doses:
- No data available
- No. of animals per sex per dose:
- approximately 6 animals
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 3 days
- Other examinations performed: Mortality observed - Statistics:
- The statistical method used to estimate the acute oral LDs0 was that of Thompson (1948) and Thompson and Weil (1952).
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 1 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No 50 % mortality observed
- Mortality:
- No 50 % mortality was observed in treated mice at 1600 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Approximate LD50 was considered to be > 1600 mg/kg bw when Deer mice were treated with 3-phenylpropanoic acid orally by gavage.
- Executive summary:
In a acute oral toxicity study, Deer mice were treated with 3-phenylpropanoic acid in a graduated dosage scale by gavage using water, corn oil, or 1.0% carbopol as carriers and observed for mortality for 3 days. No 50 % mortality was observed in treated mice at 1600 mg/kg bw. Therefore, Approximate LD50 was considered to be > 1600 mg/kg bw when Deer mice were treated with 3-phenylpropanoic acid orally by gavage.
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