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Diss Factsheets
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EC number: 605-156-9 | CAS number: 15865-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No data were found for CIL3 in the scientific literature. As a result of QSAR analysis, the substance was predicted to have an oral rat LD50 between
1800 to 2100 mg/kg bw. These data are deemed to be quite reliable since the substance is in the applicability domain of the model. In spite of this, the cut-off value, which determines the classification or the non-classification under CLP Regulation, falls into the range of predicted values.
Overall, data are judged as inconclusive for the classification.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- 1. SOFTWARE: Toxicity Estimation Software Tool (TEST)
2. MODEL (incl. version number): Oral rat LD50 (T.E.S.T. v.4.0.1 - Hierarchical clustering and FDA methods)
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL: C1CCC(CC1)NC(=O)CCCCCl
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Toxicity Estimation Software Tool (TEST), developed by EPA, meets the OECD principles for (Q)SAR model validation. More details are reported in the attached QMRF file.
- Defined endpoint: Oral rat LD50
5. APPLICABILITY DOMAIN
All details are reported in the QSAR prediction reporting attached.
6. ADEQUACY OF THE RESULT
Prediction fits the purpose of classification and labelling. - Qualifier:
- according to guideline
- Guideline:
- other: ECHA Guidance on information requirements and chemical safety assessment - Charpter R.06: QSAR and grouping of chemicals - May 2008.
- Qualifier:
- according to guideline
- Guideline:
- other: How to prepare registration and PPORD dossier - version 2.0 - September 2016.
- Principles of method if other than guideline:
- Hierarchical method – The toxicity for a given query compound is estimated using the weighted average of the predictions from several different models. The different models are obtained by using Ward’s method to divide the training set into a series of structurally similar clusters. A genetic algorithm-based technique is used to generate models for each cluster. The models are generated prior to runtime.
FDA method – The prediction for each test chemical is made using a new model that is fit to the chemicals that are most similar to the test compound. Each model is generated at runtime. - Specific details on test material used for the study:
- C1CCC(CC1)NC(=O)CCCCCl
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 1 800 - < 2 100 mg/kg bw
- Based on:
- other: QSAR prediction
- Remarks on result:
- other: QSAR prediction
- Conclusions:
- Oral rat LD50 has estimated in the range 1800-2100 mg/kg bw.
- Executive summary:
No data were found for CIL3 in the scientific literature. As a result of QSAR analysis, the substance was predicted to have an oral rat LD50 between
1800 to 2100 mg/kg bw. These data are deemed to be quite reliable since the substance is in the applicability domain of the model. In spite of this, the cut-off value, which determines the classification or the non-classification under CLP Regulation, falls into the range of predicted values.
Overall, data are judged as inconclusive for the classification.
Reference
The model Oral rat LD50 (T.E.S.T. v.4.0.1 - Hierarchical clustering and FDA methods) has estimated a value of LD50 in the range 1800 -2100 mg/kg bw.
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.