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EC number: 276-602-4 | CAS number: 72363-26-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6 September 2016 and 31 January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Specific details on test material used for the study:
- Identification: FAT 40444/B TE
Appearance/Physical state: Dark red powder
Batch: PCR92X140707 (China)
Purity: 95.4 %
Expiry date: 14 October 2019
Storage conditions: Approximately 4 °C, in the dark
Test item stored at room temperature between 14th and 18th March 2016, before transferring to 4 °C on sponsor’s authority. No impact to test item. - Radiolabelling:
- not specified
- Test temperature:
- Column temperature: 30 ºC
- Details on study design: HPLC method:
- The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
Performance of the Test
Preparation of sample solution
Test item (0.1002 g) was diluted to100 mL with acetonitrile to give a concentration of 1.00 x 103 g/L.
Preparation of dead time solution
The dead time was determined by measuring the retention time of formamide (purity* 99.94%, 659 mg/L solution in methanol: purified water (55:45 v/v)).
Preparation of reference standard solutions
Solutions of reference standards (see following table) were prepared in methanol.
Standard Purity (%)* Concentration (mg/L)
Acetanilide 99+ 109
Phenol 99.9 136
Atrazine 99.1 102
Isoproturon >98.0 114
Triadimenol 98.0 107
Linuron 99.7 104
Naphthalene 99 124
Endosulfan-diol 99.9 108
Fenthion 97.9 102
a-Endosulfan 99.6 109
Phenanthrene ≥99.5 105
Diclofop-methyl 99.1 104
DDT 98.7 106
Determination of retention time
The sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:
HPLC System: Agilent Technologies 1200 Series, incorporating autosampler and workstation
Detector type: Ultraviolet (UV)
Column: XSelect HSS Cyano 5 µm (150 x 4.6 mm id)
Column temperature: 30 ºC
Mobile phase: Methanol: pH5.5 aqueous buffer (55:45 v/v)
pH of mobile phase: 5.49
Flow-rate: 1.0 mL/min
Injection volume: 10 µL
UV detector wavelength: dead time and reference standards: 210 nm; sample: 520 nm - Analytical monitoring:
- not specified
- Details on sampling:
- N/A
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- > 5.63 dimensionless
- Sample No.:
- #2
- Type:
- log Koc
- Value:
- > 5.63 dimensionless
- Type:
- Koc
- Value:
- > 427 000 dimensionless
- Details on results (HPLC method):
- Overall log10 Koc: >5.63
Adsorption coefficient: >427000 - Details on results (Batch equilibrium method):
- The method guidelines state that the measurement of adsorption coefficient should be carried out on substances in their ionized and unionized forms (where appropriate). Testing was therefore required at pH 5.5. As the slope of the calibration curve for the reference standards showed good first order correlation and as the retention times between duplicate injections for each solution was consistent, the HPLC method was considered valid for the determination of adsorption coefficient. Based on the chromatographic data, the test item was considered to be stable during the test procedure. Chromatography showed 3 significant peaks not present within the blank solution. Peaks were at retention times of 6.4, 28.9 and 34.0 minutes. The peak at 6.4 minutes represented 1.7 % of the total area of the test item and provided log10KOC results of 3.15 (KOC 1.40 x 10^3), where as the peak at 34.0 minutes represented 0.73 % of the total area of the test item and provided log10KOC results of >5.63 (KOC >4.27 x 10^5). The test item has a purity of 95 % and therefore the largest peak has been reported.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to be greater than 427000, log10 Koc >5.63. This value indicates that the test item is immobile.
- Executive summary:
The adsorption coefficient of FAT 40444/B has been determined using the HPLC screening method, designed to be compatible with Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001 Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008. Based on the study results adsorption coefficient of FAT 40444/B is 4.27 x 105, log10 Koc >5.63. The test item is immobile.
Reference
Description of key information
The adsorption coefficient of Disperse Red 092 has been determined to be 4.27 x 105, log10Koc >5.63.
Key value for chemical safety assessment
- Koc at 20 °C:
- 427 000
Additional information
The adsorption coefficient of FAT 40444/B has been determined using the HPLC screening method, designed to be compatible with Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001 Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008. Based on the study results adsorption coefficient of of FAT 40444/B is 4.27 x 105, log10Koc >5.63. The test item is immobile. [LogKoc: 5.63]
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