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EC number: 261-867-0 | CAS number: 59703-00-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Acute oral toxicity study of Diethylcarbamoyl chloride in rat
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- diethylcarbamic chloride
- Cas Number:
- 88-10-8
- Molecular formula:
- C5H10ClNO
- IUPAC Name:
- diethylcarbamic chloride
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Diethylcarbamoyl chloride
- Molecular formula: C5H10ClNO
- Molecular weight: 135.59 g g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Diethylcarbamoyl chloride
- Molecular formula (if other than submission substance): C5H10ClNO
- Molecular weight (if other than submission substance): 135.593 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DOSAGE PREPARATION (if unusual): Compound administered undiluted as a single dose in 2000, 2350, 2600 and 2900 mg/kg bw
- Doses:
- 2000, 2350, 2600 and 2900 mg/kg bw
- No. of animals per sex per dose:
- Total: 20
2000 mg/kg bw: 2 male, 3 female
2350 mg/kg bw: 3 male, 2 female
2600 mg/kg bw: 4 male, 1 female
2900 mg/kg bw: 5 female - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: No data
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: yes
- Other examinations performed: Mortality and histopathology were examined. - Statistics:
- After approximate MLD was found. Group of rat were dosed at level designed to higher +tv toxicity rang thereby supplying data for calculation of the LD50.
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 700 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- When treated with 2900 mg/kg bw, all the five female rats were died. Half of deaths occurred in 30 minutes to two hours while the other occurred in 24 to 72 hours.
When treated with 2600 mg/kg bw, 1 male and 1 female rat died
When treated with 2350 mg/kg bw, 1 male rat died.
When treated with 2000 mg/kg bw, No mortality were observed in treated male and female rats. - Clinical signs:
- other: Muscular in coordination, lethargy, convulsions and coma were observed in died rats, Moderately severe diarrhea was observed in all surviving rats.
- Gross pathology:
- Alteration In Gastric Secretion, severally irritant intestinal mucosa, abnormally dark liver and greenish colure spleen was observed in treated rats.
- Other findings:
- Hemorrhogic area in Liver and congestion of tubule in kidney were observed in treated rats.
Any other information on results incl. tables
The Acute Oral Toxicity (LD50) of Diethylcarbamoyl Chloride for rats
Animal No.- Sex |
Weight in gm |
Doses g/kg |
Data |
1.Male |
220 |
2.00 |
Survived |
2. Male |
250 |
|
Survived |
3. Female |
195 |
|
Survived |
4. Female |
18S |
|
Died |
5. Female |
210 |
|
Survived |
6. Male |
230 |
2.35 |
Survived |
7 Male |
245 |
|
Died |
8 Male |
235 |
|
Survived |
9 Female |
200 |
|
Survived |
10 Female |
210 |
|
Survived |
11. Female |
180 |
2.60 |
Died |
12. Male |
195 |
|
Survived |
13. Male |
230 |
|
Died |
14. Male |
215 |
|
Survived |
15. Male |
200 |
|
Survived |
16. Female |
175 |
2.90 |
Died |
17. Female |
190 |
|
Died |
18 Female |
180 |
|
Died |
19. Female |
205 |
|
Died |
20. Female |
220 |
|
Died |
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was estimated to 2700 mg/kg bw when Sprague Dawlay male and female rats were treated with Diethylcarbamoyl chloride orally.
- Executive summary:
In a acute oral toxicity study,Sprague Dawlay male and female rats were treated with Diethylcarbamoyl chloride undiluted in the concentration of2000, 2350, 2600 and 2900 mg/kg bw orally by gavage.All the five female rats were died at 2900 mg/kg bw. Half of deaths occurred in 30 minutes to two hours while the other occurred in 24 to 72 hours. 1 male and 1 female rat died at 2600 mg/kg bw, 1 male rat died at 2350 mg/kg bw and No mortality were observed in treated male and female rats at 2000 mg/kg bw. Muscular in coordination, lethargy, convulsions and coma were observed in died rats. Moderately severe diarrhea was observed in all surviving rats. Decreased in 8 to 15 % body weight was observed in treated rats. In addition, Alteration In Gastric Secretion, severally irritant intestinal mucosa, abnormally dark liver and greenish colure spleen was observed in treated rats. Hemorrhogic area in Liver and congestion of tubule in kidney were observed in treated rats. Therefore,LD50 was estimated to 2700 mg/kg bw whenSprague Dawlay male and female ratswere treated withDiethylcarbamoyl chloride orally by gavage.
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