Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 700-042-6 | CAS number: 177997-13-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
- The registered substance, Lithium Cobalt Nickel Aluminium Oxide is a unique chemical substance and does not contain nickel or cobalt in the specific form of any of the carcinogenic substances referred to above. Therefore reference to these substances and their classification should be carefully considered in conjunction with existing information on the substance itself.
- The existing in vitro data, obtained from multiple studies conducted according to OECD guidelines and under GLP conditions, clearly show that Lithium Cobalt Nickel Aluminum Oxide does not express any mutagenic or clastogenic effects under the conditions of those tests.
- To date there are insufficient adequate data available to make wholly conclusive statements as to the carcinogenic potential of the substance, although all the existing in vitro mutagenicity data on the substance itself indicate a negative response
Some concerns are expressed towards the carcinogenic potential of Lithium Cobalt Nickel Aluminium Oxide, due to the classification of some of the metals and metal oxides present in the substance as carcinogenic substances. In particular nickel (EC 231-111-4) is classified as a category 2 carcinogen, while nickel monoxide (EC 215-215-7), nickel dioxide (EC 234-823-3), cobalt nickel dioxide (EC261-346-8) and cobalt lithium nickel oxide (EC 442-750-5) are classified as category 1A carcinogens according to Annex VI of the CLP regulation.
The registrant, however, would like to point out that the classification of Lithium Cobalt Nickel Aluminium Oxide as a carcinogenic substance is a conservative approach:
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.