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EC number: 283-740-9 | CAS number: 84712-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the key acute oral toxicity study in rats, conducted according to a protocol similar to OECD TG 401 and in compliance with GLP, the reported LD50 value was greater than 5000 mg/kg bw (Biosearch, 1979).
In the key acute dermal toxicity study in rats, conducted according to a protocol similar to OECD TG 402 and in compliance with GLP, the reported LD50 value was greater than 2000 mg/kg bw (Biosearch, 1979).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 July 1979 to 24 July 1979
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Expiration date of the lot/batch: no data
- Purity test date: no data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: no data
- Stability under test conditions: no data
- Solubility and stability of the test substance in the solvent/vehicle: the test substance was administered undiluted
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no data
- Preliminary purification step (if any): no data - Species:
- rat
- Strain:
- Sherman
- Remarks:
- Sherman-Wistar strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Females (if applicable) nulliparous and non-pregnant: No data
- Age at study initiation: no data
- Weight at study initiation: 200 - 300 g
- Fasting period before study: 24 hours prior to treatment the animals were deprived of food only.
- Housing: no data
- Diet: food was available, ad libitum.
- Water: water was available, ad libitum.
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: Dose volume not specified.
- Doses:
- 5.0 g/kg bw(5000 mg/kg)
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: each rat was weighed prior to administration and at the end of the study period
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Not used.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred throughout the study period.
- Clinical signs:
- other: There were no unusual clinical signs of toxicity noted.
- Gross pathology:
- Gross pathologic examination revealed nothing remarkable.
- Other findings:
- No other findings were noted. No unusual behavioural changes were noted.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the acute oral toxicity study, conducted according to a protocol similar to OECD TG 401 and in compliance with GLP, the reported LD50 value was greater than 5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 July 1979 to 24 July 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The test material was applied to abraded skin, under occlusive dressing.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Expiration date of the lot/batch: no data
- Purity test date: no data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: no data
- Stability under test conditions: no data
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no data
- Preliminary purification step (if any): no data
- Final dilution of a dissolved solid, stock liquid or gel: the test substance was applied undiluted - Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Females (if applicable) nulliparous and non-pregnant: no data
- Age at study initiation: no data
- Weight at study initiation: 2.0 and 3.0 kg
- Fasting period before study: no data
- Housing: no data
- Diet: no data
- Water: no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back (abraded)
- % coverage: no data
- Type of wrap if used: The treated areas were covered with large gauze patches and an impervious material was wrapped snugly around the trunk of each animal.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Any excess material was removed and the approximate amount remaining was noted.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data
- Constant volume or concentration used: yes
- Duration of exposure:
- 24 hours
- Doses:
- 2.0 g/kg bw (2000 mg/kg bw)
- No. of animals per sex per dose:
- 3 males and 3 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the animals were weighed prior to dosing and at the end of the study period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Not used
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred throughout the study period.
- Clinical signs:
- other: No unusual clinical or behavioural signs of toxicity were noted
- Gross pathology:
- Gross pathologic examinations revealed nothing remarkable.
- Other findings:
- No other findings were noted.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the acute dermal toxicity study, conducted according to a protocol similar to OECD TG 402 and in compliance with GLP, the reported LD50 value was greater than 2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
In the key acute oral toxicity study, conducted according to a protocol similar to OECD TG 401 and in compliance with GLP, the reported LD50 value was greater than 5000 mg/kg bw (Biosearch, 1979).
Following oral gavage administration of 5000 mg/kg bw undiluted test substance (Acetic acid, C11-14-isoalkyl esters, C13-rich) to 5 male and 5 female albino rats, all animals survived throughout the 14 -day observation period. No clinical signs of toxicity were noted in any of the test animals. The expected body weight gain was observed in all of the test animals. No macroscopic abnormalities were observed in any of the test animals at necropsy.
In the key acute dermal toxicity study, conducted according to a protocol similar to OECD TG 402 and in compliance with GLP, the reported LD50 value was greater than 2000 mg/kg bw (Biosearch, 1979).
Following a 24-hour occluded topical application of 2000 mg/kg bw undiluted test material (Acetic acid, C11-14-isoalkyl esters, C13-rich) onto the abraded skin of the back of 3 male and 3 female albino rabbits, all animals survived throughout the 14-day observation period. No clinical signs of toxicity were noted in any of the test animals. The expected body weight gain was observed in all of the test animals. No macroscopic abnormalities were observed in any of the test animals at necropsy.
Justification for classification or non-classification
Based on the available data for Acetic acid, C11-14-isoalkyl esters, C13-rich, no classification is required for acute oral or dermal toxicity according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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