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EC number: 208-358-1 | CAS number: 524-38-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer- reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity of IV-(2,3-Epoxy-propyl)-Phthalimide
- Author:
- Elliott J. Greene, Marvin A. Friedman, Michael A. Gallo. Kent R. Stevens
- Year:
- 1 979
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY 51, 197-199 (1979)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of 2-[(trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 2-[(trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione
- Cas Number:
- 133-07-3
- Molecular formula:
- C9H4Cl3NO2S
- IUPAC Name:
- 2-[(trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): 2-[(trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione
- Molecular formula : C9H4Cl3NO2S
- Molecular weight : 296.5606 g/mole
- Substance type: Organic
- Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-[(trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione
- Molecular formula (if other than submission substance): C9H4Cl3NO2S
- Molecular weight (if other than submission substance): 296.5606 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 180 and 250 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 1 %
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1000, 3000, 3500, 4000, 8000 and 1200 mg/kg
- Amount of vehicle (if gavage):
- Justification for choice of vehicle: 1% carboxymethyl cellulose
DOSAGE PREPARATION (if unusual): Dose was administered as a 25 % (w/v) water suspension with 1% carboxymethyl cellulose as a stabilizer. - Doses:
- 1000, 3000, 3500, 4000, 8000 and 12000 mg/kg
- No. of animals per sex per dose:
- Total : 50
1000 mg/kg: 5 male, 5 female
3000 mg/kg: 5 male, 5 female
3500 mg/kg: 5 male, 5 female
4000 mg/kg: 5 male, 5 female
8000 mg/kg: 5 male, 5 female
1200 mg/kg : 5 male, 5 female - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed: no
- Other examinations performed: Mortality, Clinical sign and gross pathology were examined. - Statistics:
- The acute oral LD50 was calculated according to Knudsen and Curtis (1947).
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 47 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 500 - 5 900
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- When treated with 4000, 8000 and 12000 mg/kg, all animals died on day 0 and Day 1, except one animal at 4000 mg/kg which died on Day 3.
- Clinical signs:
- other: Salivation, decreased activity, bloody nasal discharge, and ataxia at 3000 and 3500 mg/kg and, in addition, decreased respiration, in coordination, and gasping at 4000, 8000 and 12000 mg/kg With the exception of salivation and incoordination which disa
- Gross pathology:
- In lungs, liver and gastrointestinal tract toxicity were observed
At all doses, the lungs were dark and mottled and the gastrointestinal tract was vascularized.
The liver was pale or pale and mottled at 3500 and 3000 mg/kg, respectively, and dark or dark and mottled at 4000, 8000 and 12000 mg/kg. - Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 4700 mg/kg bw when Sprague-Dawley male rats were treated with 2-[(trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione orally by gavage.
- Executive summary:
In a acute oral toxicity studySprague-Dawley male rats were treated with 2-[(trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione in the concentration of 1000, 3000, 3500, 4000, 8000 and 12000 mg/kg orally by gavage and observed for 14 days. At 4000, 8000 and 12000 mg/kg, All animals died on day 0 and Day 1, except one animal at 4000 mg/kg which died on Day 3. Salivation, decreased activity, bloody nasal discharge, and ataxia at 3000 and 3500 mg/kg and, in addition, decreased respiration, in coordination, and gasping at 4000, 8000 and 12000 mg/kg With the exception of salivation and incoordination which disappeared within 24 hr, these signs persisted for several days. In addition, In lungs, liver and gastrointestinal tract toxicity was observed at all doses, the lungs were dark and mottled and the gastrointestinal tract was vascularized.
The liver was pale or pale and mottled at 3500 and 3000 mg/kg, respectively, and dark or dark and mottled at 4000, 8000 and 12000 mg/kg. Therefore,LD50 was considered to be4700mg/kg bw whenSprague-Dawley male rats were treated with 2-[(trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione orally by gavage.
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