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Diss Factsheets
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EC number: 252-276-9 | CAS number: 34893-92-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: inhalatio hazard test
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Test substance was liquefied at 30°C and evaporated. 200 l of air were conducted through 50 g of test substance and given 5 male and 5 female rats respectively for inhalation. Animals were housed in a 10 l chamber and trated for 10 or 30 min, 1, 3 or 7 hours.
- GLP compliance:
- not specified
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- 1,3-dichloro-5-isocyanatobenzene
- EC Number:
- 252-276-9
- EC Name:
- 1,3-dichloro-5-isocyanatobenzene
- Cas Number:
- 34893-92-0
- Molecular formula:
- C7H3Cl2NO
- IUPAC Name:
- 1,3-dichloro-5-isocyanatobenzene
- Details on test material:
- lot no 2270
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- >= 10 - <= 420 min
- Concentrations:
- air saturated with test subsance
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: Lt50
- Effect level:
- >= 30 other: min
- Exp. duration:
- 30 min
- Remarks on result:
- other: 50% of the animals died in a saturated test atmosphere with 3,5-dichlorphenyl isocyanate
- Mortality:
- 50 % of the animals died between 30 min and 60 min in a atmosphere saturated with 3,5-dichlorophenyl isocyanate
- Clinical signs:
- other: abnormal behaviour, laboured breathing, reddening of eyes and nose, lacrimation
- Body weight:
- rats which were exposed only for 10 min showed normal weight gain. surviving animals of an exposure of 30 min or above showed a clear weight loss
- Gross pathology:
- reddish dicolored, edematous and inflated lungs, which were discolored dark reddish after 10 min and greyish or reddish after 30 min
Any other information on results incl. tables
clinical signs: abnormal behaviour, laboured breathing. during the first post-observation day the visible mucosa of eyes and nose were reddened and an elevated lacrimation was seen
pathology: dark red discoloured, edematous and inflated lungs.
Applicant's summary and conclusion
- Interpretation of results:
- very toxic
- Remarks:
- Migrated information
- Executive summary:
Test substance was liquefied at 30°C and evaporated. 200 l of air were conducted through 50 g of test substance and given 5 male and 5 female rats respectively for inhalation. Animals were housed in a 10 l chamber and treated wholebody for 10 or 30 min, 1, 3 or 7 hours. 50 % of the animals died after an exposure time between 30 and 60 minutes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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