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EC number: 255-062-3 | CAS number: 40754-59-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from J-CHECK
Data source
Reference
- Reference Type:
- other: Authoritative database
- Title:
- Single Dose Oral Toxicity study of Sodium 1-methoxycarbonylpentadecane-2-sulfonate in rats
- Author:
- J-CHECK
- Year:
- 2 010
- Bibliographic source:
- Ministry of Health, Labour and Welfare", "Ministry of the Environment" and "National Institute of Technology and Evaluation, J-CHECK, 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Acute Oral Toxicity study of Sodium 1-methoxycarbonylpentadecane-2-sulfonate in rats.
- GLP compliance:
- not specified
- Test type:
- other: Single Dose Oral Toxicity study
- Limit test:
- no
Test material
- Reference substance name:
- sodium 1-methoxy-1-oxohexadecane-2-sulfonate
- Cas Number:
- 4016-24-4
- Molecular formula:
- C17H34O5SNa
- IUPAC Name:
- sodium 1-methoxy-1-oxohexadecane-2-sulfonate
- Details on test material:
- - Name of test material (as cited in study report): Sodium 1-methoxycarbonylpentadecane-2-sulfonate
- Molecular formula (if other than submission substance): C17H33NaO5S
- Molecular weight (if other than submission substance): 372.50 g/mole
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Sodium 1-methoxycarbonylpentadecane-2-sulfonate
- Molecular formula (if other than submission substance): C17H33NaO5S
- Molecular weight (if other than submission substance): 372.50 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Remarks:
- IGS
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0, 786, 983, 1229, 1536, 1920, 2400 mg/kg
- Amount of vehicle (if gavage): No data available
- Justification for choice of vehicle: Olive oil - Doses:
- 0, 786, 983, 1229, 1536, 1920, 2400 mg/kg
- No. of animals per sex per dose:
- Total: 70
0 mg/kg: 5 male, 5 female
786 mg/kg: 5 male, 5 female
983 mg/kg: 5 male, 5 female
1229 mg/kg: 5 male, 5 female
1536 mg/kg: 5 male, 5 female
1920 mg/kg: 5 male, 5 female
2400 mg/kg: 5 male, 5 female - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: No data available
- Frequency of observations and weighing: Yes
- Necropsy of survivors performed: yes
- Other examinations performed: Survival, clinical signs, body weight and gross pathology were examined. - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 142 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 819
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- n male, when treated with 983, 1229, 1536, 1920, 2400 mg/kg, Deaths was observed 6 to 24 hours after administration.
In female, 1536, 1920, 2400 mg/kg, Deaths was observed 6 to 24 hours after administration. - Clinical signs:
- other: Decreased locomotor activity, ptosis, diarrhea, soiling of the perineal region and piloerection were observed in treated groups. Most clinical signs in the survivors showed a tendency for recovery on the day following administration and all had disappeare
- Gross pathology:
- Distention of the stomach with a watery content was observed in most of the animals which died
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be to 2142 mg/kg bw for male and 1819 mg/kg bw for female when Crj:CD(SD)IGS male and female rats were treated Sodium 1-methoxycarbonylpentadecane-2-sulfonate orally by gavage.
- Executive summary:
In a acute oral toxicity study, Crj: CD(SD)IGS male and female ratswere treatedSodium 1-methoxycarbonylpentadecane-2-sulfonate in the concentration of0, 786, 983, 1229, 1536, 1920, 2400 mg/kgorally by gavage in Olive oil. Deaths was observed 6 to 24 hours after administration in male rats at 983, 1229, 1536, 1920, 2400 mg/kg and in female rats at 1536, 1920, 2400 mg/kg.Decreased locomotor activity, ptosis, diarrhea, soiling of the perineal region and piloerection were observed in treated groups. Most clinical signs in the survivors showed a tendency for recovery on the day following administration and all had disappeared after 6 days. In addition, Dose dependent decrease in body weights were observed in treated male and female rats. However, a tendency for recovery was noted 3 days after the administration. Distention of the stomach with a watery content was observed in most of the animals which died. Therefore,estimated LD50 was considered to be 170000 mg/kg bw when rat were treateddisodium 4-oxo-2-sulfonato-5,8,11,14-tetraoxahexacosan-1-oate orally.
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