Registration Dossier
Registration Dossier
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EC number: 227-086-4 | CAS number: 5638-76-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- No data on method, no data on GLP.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
- Principles of method if other than guideline:
- No data on method
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Betahistine
- EC Number:
- 227-086-4
- EC Name:
- Betahistine
- Cas Number:
- 5638-76-6
- Molecular formula:
- C8H12N2
- IUPAC Name:
- methyl[2-(pyridin-2-yl)ethyl]amine
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 920 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No data available.
- Clinical signs:
- No data available.
- Body weight:
- No data available.
- Gross pathology:
- No data available.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 in mouse is 2920 mg/kg.
- Executive summary:
The acute oral toxicity of the test substance was evaluated on mice. According to the results, the oral LD50 is 2920 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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