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Diss Factsheets
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EC number: 944-251-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 16 June - 30 June, 1980
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Remarks:
- This study was conducted in compliance with the FDA's Good Laboratory Practices effective 6/20/79.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-butyl-3,6-dihydro-4,6-dimethyl-2H-pyran
- EC Number:
- 246-099-6
- EC Name:
- 2-butyl-3,6-dihydro-4,6-dimethyl-2H-pyran
- Cas Number:
- 24237-01-2
- Molecular formula:
- C11H20O
- IUPAC Name:
- 2-butyl-4,6-dimethyl-3,6-dihydro-2H-pyran
- Reference substance name:
- 6-butyl-3,6-dihydro-2,4-dimethyl-2H-pyran
- EC Number:
- 246-098-0
- EC Name:
- 6-butyl-3,6-dihydro-2,4-dimethyl-2H-pyran
- Cas Number:
- 24237-00-1
- Molecular formula:
- C11H20O
- IUPAC Name:
- 6-butyl-2,4-dimethyl-3,6-dihydro-2H-pyran
- Reference substance name:
- 2-butyltetrahydro-6-methyl-4-methylene-2H-pyran
- EC Number:
- 246-101-5
- EC Name:
- 2-butyltetrahydro-6-methyl-4-methylene-2H-pyran
- Cas Number:
- 24237-02-3
- Molecular formula:
- C11H20O
- IUPAC Name:
- 2-butyl-6-methyl-4-methylenetetrahydro-2H-pyran
Constituent 1
Constituent 2
Constituent 3
- Specific details on test material used for the study:
- Material Identification (as stated in the report) : Gyrane #80-38
Appearance: Clear liquid
Sample received on 06/02/80
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals
- Age at study initiation: approx. 8 weeks old
- Weight at study initiation: 202 - 268 g
- Fasting period before study: 16-20 hours
- Housing: Five animals per cage were housed in suspended wire mesh cages.
- Diet: Fresh Purina rat chow was freely available
- Water: Water was freely available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test arzicle was given by orally by syringue and a dosing needle.
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: the animals were observed 3-4 hours after dosing and once daily for 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: mortality, toxicity and clinical signs, gross pathology.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- One instance of chromodacryorrhea was noted 3-4 hours post dose.
Isolated instances of hyperactivity, prostration, piloerection, ptosis, tachypnea and chromodacryorrhea were noted during the study. Nine animals were normal on day 14.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity with male Wistar rats performed equivalent to OECD 401 guideline, a LD50 >5000 mg/kg bw was determined.
- Executive summary:
Gyrane was tested in an acute oral toxicity study with male Wistar rats at 5000 mg/kg body weight. The study was performed equivalent to OECD 401 guideline and according to GLP principles.
No mortality occurred in 10 male rats from an oral dose of Gyrane, at 5.0 g/Kg. Minimal toxic signs were present and the necropsy findings were normal.
Thus, the LD50 of Gyrane was determined to be : LD50>5000 mg/kg bw.
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