Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-207-2 | CAS number: 2156592-65-1
Endpoint summary
Administrative data
Description of key information
Data for a bioaccumulation in aquatic sediments was reviewed. In a bioconcentration study performed according OECD Guideline 305 (Bioconcentration: Flow-through Fish Test), rainbow trout (Oncorhynchus mykiss) were exposed to 14-C SP6012 (oil free) at concentrations of 0.001 and 0.01 mg/L under dynamic conditions. 14-C SP6012 (oil free) was not significantly accumulated in fish tissue and was observed to be eliminated over a 61-day depuration period. The calculated BCF was 45 and 38 at 0.001 mg/L (steady state and kinetic state respectively) and 58 and 64 at 0.01 mg/L (steady state and kinetic state respectively).
This toxicity study is classified as acceptable and satisfies the guideline requirement for a fish bioaccumulation study.
Additional information
The prediction of the BCF was performed with the computer program BCFBAF v3.01 (EPIWIN software) by US-EPA (ATL, 2016x). In general, the bioconcentration factor of a substance describes the accumulation potential of a substance dissolved in water by an aquatic organism. BCFBAF v3.01 calculates also the BAF (Bioaccumulation factor) of the chemical, which is defined as the steady-state (equilibrium) ratio of the substance concentration in an organism to the concentration in the surrounding medium. However, this value is not taken into account for the risk assessment and is not relevant for a registration under REACH Regulation (EC) 1907/2006. Using the regression-based estimate (traditional method) of the computer program BCFBAF from US-EPA a Bioconcentration Factor (BCF) of 70.79 L/kg wet-wt was calculated for the test substance. Using the Arnot-Gobas method, which is based on mechanistic first principles, an aquatic BCF of 2.365 was estimated. The whole body primary biotransformation rate estimate for fish results is an estimated half-life of 15.66 days, whereby the bio half-life is normalized to 10 g fish at 15 °C. With the Arnot-Gobas method it is possible to estimate the upper trophic level. For the upper trophic level, the BCF results in a BCF of 2.365. As conclusion it can be stated, that a strong bioaccumulation in aquatic organisms is unlikely
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
