Registration Dossier
Registration Dossier
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EC number: 928-842-2 | CAS number: 1184648-08-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (3h), bacteria [(R)-2-(4-hydroxyphenoxy)-propanoic acid] > 100 mg/L (Grade 1996)
Key value for chemical safety assessment
- EC50 for microorganisms:
- 100 mg/L
Additional information
The acute toxicity of the test item was measured in an activated sludge respiration inhibition assay according to OECD Guideline 209 and EU Method C.11 under GLP. The inhibitory effect of the test substance was expressed as a percentage of the mean respiration rates of two controls. Following values were based on nominal concentrations. Decrease in respiration rate (inhibition) after incubation with the test item was always ≤ 15% with no visible dose response. The EC50 (3h) was found to exceed the highest tested concentration of 100 mg/L.
Potassium (R)-2-(4-hydroxyphenoxy)propionate, when dissolved in water becomes equal to the test item (R)-2-(4-hydroxyphenoxy)propanoic acid and toxicity to baxtreia of the potassium salt is therefore equal to the toxicity to bacteria measured for the acid. It can therefore be concluded by read-across without reasonable doubt that the EC50 (3h) of potassium (R)-2-(4-hydroxyphenoxy)propionate is >100 mg/L.
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