Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
hydrolytically stable (LC-MS-MS method, OECD 111)
Key value for chemical safety assessment
Additional information
A hydrolysis study was conducted by Johannes (2015). The study was done according to GLP and followed OECD guideline 111. The test item was added to sterilised buffer solutions (pH values: 4, 7, and 9) using a stock solution in methanol. Spiked solutions were stored at 50 °C for a period of five days. Samples were taken at the beginning and after five days. The experiment for Tier 1 was performed twice. Experiment 1 was judged invalid due to apparently wrong measurement of the starting concentrations using LC-MS-MS. The analysis of the samples of experiment 2 showed no decrease >10 %. Therefore, the test substance is considered hydrolytically stable.
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