Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No specific study was performed on the absorption, distribution, metabolism, excretion (ADME) of this substance (WS400102), but data are currently available fromin vivoandin vitrotoxicology studies.
The substance WS400102 is a complex mixture of components (UVCB), a physical mixture / salt of tall-oil fatty acids and technical triethanolamine (TEA). Tall-oil fatty acids are derived from plant material with varying composition of mostly C18fatty acids, saturated, mono- and poly-unsaturated.
Absorption
WS400102 has low water solubility (249 mg/L at 20°C) and relatively high lipophilicity (Log10Pow2.1-5.0 at 25°C). The molecular weight ranges from approx. 150 Da to approx. 340 Da (monoester). Based on these properties some part of WS400102 would be expected to be absorbed after topical administration. Due to the fact that the substance is irritating to skin dermal penetration may be enhanced [ECHA 2008].
Absorption after oral administration of WS400102 is rather likely. Fatty acids or their glycerol esters are normal ingredients of food and are absorbed. Absorption of WS400102 after oral gavage administration is concluded from changes in a number of blood plasma parameters, increased liver weight and minimal changes in kidneys of females at 1000 mg/kg/day in the repeat dose toxicity study.
No data is available on absorption after inhalation. However, inhalation of any vapour from WS400102 is an unlikely route of human exposure, because the substance has very low vapour pressure (0.01 Pa at 25°C) and decomposes at high temperatures (> 227°C). Exposure of humans to an inhalable aerosol of WS400102 is also unlikely, because it is a highly viscous liquid limiting its availability as an inhalable aerosol.
Distribution
Based on the chemical composition of WS400102 it is expected that the fatty acids are absorbed and distributed in the body like any dietary fatty acids. TEA after absorption is expected to be freely distributed in tissues due to its high water solubility.
Metabolism
The tall-oil fatty acids contained in the UVCB substance WS400102 are expected to be metabolised like other fatty acids taken up with the daily diet. Mono-esters of fatty acids probably will be hydrolysed releasing fatty acids. Triethanolamine is well water soluble and thus probably will be excreted in urine.
Excretion
Triethanolamine is well water soluble and thus probably will be excreted in urine whereas fatty acids are expected to be metabolised like other dietary fatty acids. Thus, bioaccumulation of WS400102 or any components is rather unlikely.
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