Registration Dossier
Registration Dossier
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EC number: 228-491-9 | CAS number: 6281-42-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-05-27 until 2016-10-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 22 september 2015
- Type of method:
- flask method
- Water solubility:
- > 555.5 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 11.66 - <= 11.75
- Remarks on result:
- completely miscible
- Details on results:
- Based on the measured concentrations the test mixtures were homogeneous and the whole amount of the added test substance was dissolved.
As the measured concentrations correspond to the total dissolution of the test substance, and also based on the justification measurement, water solubility of AEEU is higher than 555.5 g/L (nominal concentration) at 20°C. - Conclusions:
- The solubility of the test item is higher than 555.5 g/L at 20°C with a pH between 11.66 to 11.75.
- Executive summary:
The water solubility of the test item was determined according to recognized international Guidelines (EU Method A.6 and OECD 105) and under GLP. No deviation from the guideline was observed during the study.
The substance is dissolving in water without restraint. Therefore a mixture of test item of 500 mg/mL solution was prepared. Subsequently, the mass concentration of the substance in the aqueous solution is determined by an appropriate analytical method.
Based on the results, the solubility of the test item was found to be higher than 555.5 g/L at 20°C with a pH between 11.66 to 11.75.
Reference
Table: Results of the determination of the test item concentrations
Nominal Concentration mg/mL |
pH |
Calculated concentration mg/mL |
Mean mg/mL |
Recovery% |
555.5 |
11.75 |
551.8 |
555.1 |
100 |
558.4 |
||||
553.4 |
11.70 |
555.4 |
555.4 |
100 |
555.4 |
||||
554.4 |
11.73 |
555.0 |
553.5 |
100 |
552.1 |
||||
447.0 |
11.66 |
446.4 |
446.0 |
100 |
445.7 |
||||
551.7 |
11.68 |
541.4 |
542.0 |
98 |
2.7 |
Description of key information
The water solubility of the test item was determined according OECD 105 and under GLP. No deviation from the guideline was observed during the study.
The solubility of the test item is higher than 555.5 g/L at 20°C with a pH between 11.66 to 11.75.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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