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Diss Factsheets
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EC number: 269-246-6 | CAS number: 68201-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- Direct Red 253
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- Direct Red 253
- Name:
- Direct Red 253
- Type of composition:
- boundary composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- Direct Red 253
- PBT status:
- the substance is not PBT / vPvB
- Justification:
PERSISTENCE
Because of the chemical structure and functional groups presents, hydrolysis can be considered as negligible degradation pathway and the substance is not expected to be ready biodegradable. The biodegradability potential estimated based on QSAR/QSPR prediction confirmed this expectation. However, the available information do not permit to reach a conclusion about the inherently biodegradation potential, thus it is not known if the substance has a potential for persistence (P or vP). A conclusion about the P-criterion cannot be reached.
BIOACCUMULATION
There are no empirical bioaccumulation data available for Direct Red 253, however the log Kow was experimentally determined to be -1.98 ± 0.11 at 23 °C and pH 6.5 (Havránková, 2016). Thus, due to the physicochemical properties, the substance is expected to possess a low potential to cross biological membranes.
TOXICITY
Aquatic long-term toxicity data are not available for Direct Red 253, nevertheless short-term toxicity studies show that the substance does not cause adverse effects on aquatic organisms and it does not meet the criteria to be classified hazardous for aquatic life. The substance is not classified as carcinogenic (category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B or 2) according to Regulation EC No 1272/2008 and there are no other evidence of chronic toxicity, as identified by the classifications specific target organ toxicity after repeated exposure (STOT RE category 1 or 2) according to Regulation EC No 1272/2008.
Although the substance is expected to not meet the criteria to be considered T, a conclusion about the T-criterion cannot be reached in agreement with the REACH Regulation (EC 1907/2006).
CONCLUSION
According to the REACH Regulation (EC 1907/2006), Annex XIII, a substance that fulfils the persistence, bioaccumulation and toxicity criteria shall be considered to be a PBT substance. Taken into account the available data, Direct Red 253 does not meet all the three criteria to be considered as a PBT substance.
Referenceopen allclose all
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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