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EC number: 701-052-3 | CAS number: 146987-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
readily biodegradable, OECD guideline 301 F / EU method C.4-D (Manometric Respirometry Test), GLP, RL1; read-across: Amides, C8-18 even numbered, N-[3-(dimethylamino)propyl]
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
For the assessment of the biodegradability of Amides, C8-18, C18 unsatd, N-[3-(dimethylamino)propyl] a study conducted with the closely related source substance Amides, C8-18 even numbered, N-[3-(dimethylamino)propyl] is available.
Supporting data on the target substance itself is also available. The studies, however, are insufficiently documented.
A justification for read-across is given in IUCLID section 13.
The ready biodegradation of Amides, C8-18 even numbered, N-[3-(dimethylamino)propyl] was investigated in a study conducted according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) and EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test) over a period of 28 days and using domestic activated sludge as inoculum. The biodegradation rate was determined by measurement of oxygen consumption. Inoculum blank, abiotic control, procedural/functional control with the reference substance sodium benzoate, and toxicity control using 100 mg/L test item and 100 mg/L reference compound were performed.
The test item proved to be readily biodegradable at a test substance concentration of 25 mg/L (81% biodegradation after 28 d). At a concentration of 100 mg/L, the test substance was biodegraded by 57% after 28 d; thus, the pass level of 60% biodegradation was not reached. However, due to the high ThOD of 2.73 mg O2/mg test substance, the test item suspension with a concentration of 25 mg/L met the criteria of 50 -100 mg ThOD or COD/L as demanded in the guideline.
No significant nitrification was observed until test end (at most 7.6% of theoretical NO3 production in the higher concentrated assay). No abiotic degradation of the test item was observed.
The reference item sodium benzoate was biodegraded by 90% after 14 days and thus fulfilling the guideline requirements.
In the toxicity control (100 mg/L test and reference substance each) the biodegradation amounted to 62% after 14 d. Thus, the test item can be considered as non toxic to the inoculum. The oxygen uptake of the inoculum blank was < 60 mg/L in 28 d and the pH was inside the range of 6.0 -8.5. The difference of extremes of replicate values of the removal of the test item at the end of the test was less than 20%.
The test item was readily biodegradable and fulfilled the 10-d window criterion.
Two supporting studies conducted with the target substance Amides, C8-18, C18 unsatd, N-[3-(dimethylamino)propyl] are also available:
In a study according to EU test method C.4-E, the test substance Amides, C8-18, C18 unsatd, N-[3-(dimethylamino)propyl] was degraded by more than 80% in 28 days. Therefore, it is considered to be readily biodegradable.
In a study according to OECD test guideline 301D, the test substance Amides, C8-18, C18 unsatd, N-[3-(dimethylamino)propyl] was degraded by 65% within 28 days. Therefore, it is considered as readily biodegradable, but failing the 10-day window.
Considering all available data, the substance is regarded to be readily biodegradable.
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