Registration Dossier
Registration Dossier
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EC number: 233-786-0 | CAS number: 10361-29-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Significant methodological deficiencies (only 2 Salmonella strains tested)
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Fujita H, Aoki N, Sasaki M
- Year:
- 1 994
- Bibliographic source:
- Ann. Rep. Tokyo Metr. Res. Lab. P. H., 45, 191-199
Materials and methods
- Principles of method if other than guideline:
- preincubation procedure described by Ames et al; only 2 Salmonella strains tested
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Diammonium carbonate
- EC Number:
- 208-058-0
- EC Name:
- Diammonium carbonate
- Cas Number:
- 506-87-6
- Molecular formula:
- CH2O3.2H3N
- IUPAC Name:
- diammonium carbonate
- Reference substance name:
- Ammonium carbonate
- EC Number:
- 233-786-0
- EC Name:
- Ammonium carbonate
- Cas Number:
- 10361-29-2
- Molecular formula:
- CH2O3.xH3N
- IUPAC Name:
- diammonium carbonate
Constituent 1
Constituent 2
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 97
- Species / strain / cell type:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix
- Test concentrations with justification for top dose:
- 0, 0.1, 0.5, 1, 5, and 10 mg/plate
- Vehicle / solvent:
- DW (presumably distilled water)
Controls
- Negative solvent / vehicle controls:
- yes
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA 97 and TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
