Registration Dossier
Registration Dossier
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EC number: 805-733-7 | CAS number: 256504-39-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Study period:
- Oct 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Internal QSAR Toolbox 4.2 query conducted and full report written.
Data source
Materials and methods
Test material
- Reference substance name:
- ethyl 5-amino-1-[(2-fluorophenyl)methyl]-1H-pyrazole-3-carboxylate
- EC Number:
- 805-733-7
- Cas Number:
- 256504-39-9
- Molecular formula:
- C13H14FN3 O2
- IUPAC Name:
- ethyl 5-amino-1-[(2-fluorophenyl)methyl]-1H-pyrazole-3-carboxylate
- Test material form:
- solid
Constituent 1
Results and discussion
Any other information on results incl. tables
QSAR Toolbox protein binding profiler | Result | within applicability domain of profiler |
Protein binding by OASIS | No alert found
| yes |
Protein binding by OECD | No alert found
| yes |
Protein binding alerts for skin sensitisation according to GHS | No alert found
| yes |
Protein binding alerts for skin sensitisation by OASIS | No alert found
| yes |
Protein binding potency Cys (DPRA 13%) | DPRA less than 9% (DPRA 13%) DPRA less than 9% (DPRA 13%) >> Mono-halo arenes
| yes |
Protein binding potency Lys (DPRA 13%) | DPRA less than 9% (DPRA 13%) DPRA less than 9% (DPRA 13%) >> Mono-halo arenes | yes |
Protein binding potency GSH | Not possible to classify according to these rules (GSH) | yes |
Protein binding potency h-CLAT | Monohaloarenes | yes |
Keratinocyte gene expression | Not possible to classify according to these rules
| yes |
Applicant's summary and conclusion
- Executive summary:
Alerts for protein binding are found by 1 (out of nine) QSAR Toolbox 4.2 profilers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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