Registration Dossier
Registration Dossier
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EC number: 203-738-3 | CAS number: 110-13-4
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish short-term toxicity test on embryo and sac-fry stages
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2002
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Entwicklung und Erprobung eines Teratogenitäts-Screening Testes mit Embryonen des Zebrabärblings Danio rerio
- Author:
- Jean Bachmann
- Year:
- 2 002
- Bibliographic source:
- Dissertation zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) an der Fakultät für Forst-, Geo- und Hydrowissenschaften der Technischen Universität Dresden
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Danio rerio Teratogenicity Assay
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexane-2,5-dione
- EC Number:
- 203-738-3
- EC Name:
- Hexane-2,5-dione
- Cas Number:
- 110-13-4
- Molecular formula:
- C6H10O2
- IUPAC Name:
- hexane-2,5-dione
- Test material form:
- not specified
- Details on test material:
- > 98 %, Sigma-Aldrich (Steinheim, Germany)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48
- Remarks on exposure duration:
- h
- Post exposure observation period:
- 48 hours
Test conditions
- Nominal and measured concentrations:
- 10,5; 15,8; 23,7; 35,5 and 53,2 mmol/L
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 40 other: mmol/L
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
