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EC number: 210-441-2 | CAS number: 615-66-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from predictive model developed by US EPA.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Prediction is done using BCFBAF Program (v3.01) of EPI Suite model.
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fish
- Route of exposure:
- aqueous
- Test type:
- other: Estimation
- Test temperature:
- 25 deg C
- Reference substance (positive control):
- not specified
- Temp.:
- 25 °C
- Type:
- BCF
- Value:
- 3.162 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- other: estimated
- Remarks on result:
- other: Non bioaccumulative
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The bioconcentration factor (BCF) for 2-chloro-p-phenylenediamine is estimated as 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000 as per Annex XIII of REACH regulation. Thus, it is concluded that 2-chloro-p-phenylenediamine (CAS No. 615-66-7) does not qualify as bio-accumulative substance. This BCF also suggests the potential for bioconcentration in aquatic organisms is low.
- Executive summary:
The BCFBAF program v3.01 of Estimation Programs Interface (EPI) Suite (2017) prediction model was used to predict the bioconcentration factor of 2-chloro-p- phenylenediamine (CAS No. 615-66-7). The bioconcentration factor (BCF) for 2-chloro-p-phenylenediamine is estimated as 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000 as per Annex XIII of REACH regulation. Thus, it is concluded that 2-chloro-p-phenylenediamine (CAS No. 615-66-7) does not qualify as bio-accumulative substance. This BCF also suggests the potential for bioconcentration in aquatic organisms is low.
Reference
BCFBAF Program (v3.01) Results:
==============================
SMILES : Nc(c(cc(N)c1)CL)c1
CHEM : 1,4-Benzenediamine, 2-chloro-
MOL FOR: C6 H7 CL1 N2
MOL WT : 142.59
--------------------------------- BCFBAF v3.01 --------------------------------
Summary Results:
Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)
Biotransformation Half-Life (days) : 0.0222 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): -0.01 (BAF = 0.982 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: 0.25
Equation Used to Make BCF estimate:
Log BCF = 0.50
Correction(s): Value
Correction Factors Not Used for Log Kow < 1
Estimated Log BCF = 0.500 (BCF = 3.162 L/kg wet-wt)
Description of key information
The BCFBAF program v3.01 of Estimation Programs Interface (EPI) Suite (2017) prediction model was used to predict the bioconcentration factor of 2-chloro -p-phenylenediamine (CAS No. 615-66-7). The bioconcentration factor (BCF) for 2-chloro-p-phenylenediamine is estimated as 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000 as per Annex XIII of REACH regulation. Thus, it is concluded that 2-chloro-p-phenylenediamine (CAS No. 615-66-7) does not qualify as bio-accumulative substance. This BCF also suggests the potential for bioconcentration in aquatic organisms is low.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.162 L/kg ww
Additional information
The substance 2-chloro-p-phenylenediamine (CAS No. 615-66-7) has been investigated for its environmental bioconcentration potential (BCF) to a greater or lesser extent. These include various predicted result from validated model for target chemical 2-chloro-p-phenylenediamine (CAS No. 615-66-7)and experimental data for its read across substances 3-chloroaniline (CAS No.- 108-42-9) and 3,4-dichloroaniline (CAS No.- 95-76-1) by considering its structure-activity relationships. The studies are summarized as follows:
The BCFBAF program v3.01 of Estimation Programs Interface (EPI) Suite (2017) prediction model was used to predict the bioconcentration factor of 2-chloro-p-phenylenediamine (CAS No. 615-66-7). The bioconcentration factor (BCF) for 4-chloro-o-phenylenediamine is estimated as 3.162 L/kg wet-wt.
In a study conducted by T. Tsuda et al. (Chemosphere 1993, 26(12), 2301-2306.), the bioconcent ration factor (24-336 hr exposure) for carp exposed to 14.7 and 0.67 µg/L under continuous flow-through conditions, 0.8 and 2.2, respectively. Whole-body excretion rate constant 0.21 hr-1. This low value of BCF indicates that 3-chloroaniline does not qualify as bio-accumulative substance as the BCF factor is less than the bio-concentration threshold of 2000 as per Annex XIII of REACH regulation. This BCF also suggests the potential for bioconcentration in aquatic organisms is low.
Moreover, based on the study from an authoritative database [HSDB(Hazardous Substances Data Bank) (2017)], a BCF of 30.2 was determined for 3,4-dichloroaniline under static conditions with 60 male zebra fish for 10 hours. According to a classification scheme, this BCF suggests the potential for bioconcen tration in aquatic organisms is low.
Based on the above predicted studies for target substance 2-chloro-p-phenylenediamine (CAS No. 615-66-7) and to its read across substances 3-chloroaniline (CAS No.- 108-42-9) and 3,4-dichloroaniline (CAS No.- 95-76-1), the bioconcentration factor (BCF) was found to be in the range of 0.8 – 30.2 (dimension less or L/kg wet-wt) at temperature 25 degC. These BCF values does not exceed the bioconcentration threshold of 2000 as per Annex XIII of REACH regulation. Thus, it is concluded that 2-chloro-p-phenylenediamine (CAS No. 615-66-7) does not qualify as bio-accumulative substance. This BCF also suggests the potential for bioconcentration in aquatic organisms is low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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