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Diss Factsheets
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EC number: 247-825-4 | CAS number: 26586-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-03-23 (day of application)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- (E)-3-formylbut-2-enyl acetate
- EC Number:
- 247-825-4
- EC Name:
- (E)-3-formylbut-2-enyl acetate
- Cas Number:
- 26586-02-7
- Molecular formula:
- C7H10O3
- IUPAC Name:
- (2E)-3-methyl-4-oxobut-2-en-1-yl acetate
- Details on test material:
- - Name of test material (as cited in study report): C5-Acetat
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
2 male and 1 female Vienna White rabbits
- Source: Gaukler, 6050 Offenbach, Germany
- Age at study initiation: no data
- Weight at study initiation: 3.82 (animal no. 1; male); 2.70 kg (animal no. 2; male); 2.92 kg (animal no. 2; female)
- Housing: individually in stainless steel cages, area 40 cm x 51 cm
- Diet: ca. 130 g/day; Ovator Solikanin 4 mm; Muskator, Düsseldorf, Germany
- Water: ca. 250 ml/day
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 26 °C
- Humidity (%): 30 - 70 %
- Air changes (per hr): 15-20
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin sites of the test animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): ca. 0.5 ml of the unchanged test substance - Duration of treatment / exposure:
- 1 hour
- Observation period:
- 8 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: upper third of the back or flanks; a test patch (ca. 2.5 cm x 2.5 cm) was soaked with 0.5 ml of the liquid test substance
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol and Lutrol/water (1:1)
- Time after start of exposure: 1 h
SCORING SYSTEM: Draize / OECD
The skin of each animal was read at 30-60 minutes after removal of the application patches as well as at 24 hours, 48 hours, 72 hours, and 8 days after beginning of application.
After sacrifice, the animals were subjected to gross pathology.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of n=3
- Time point:
- other: 24 - 72 h
- Score:
- 1.56
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of n=3
- Time point:
- other: 24 - 72 h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible
Any other information on results incl. tables
Table: Individual scores and findings
Reading |
Animal no. |
Erythema |
Edema |
Symptoms |
24 h |
1 |
2 |
0 |
R:U |
|
2 |
2 |
0 |
R:U |
|
3 |
2 |
1 |
R:U/OE:U |
48 h |
1 |
1 |
0 |
R:U |
|
2 |
1 |
0 |
R:U |
|
3 |
2 |
1 |
R:U/OE:U |
72 h |
1 |
1 |
0 |
R:U |
|
2 |
1 |
0 |
R:U |
|
3 |
2 |
1 |
|
8 d |
1 |
1 |
0 |
|
|
2 |
1 |
0 |
R:U |
|
3 |
1 |
0 |
S |
Abbreviations:
OE:U = edema exceeds the application area
R:U = erythema exceeds the application area
S= desquamation
Applicant's summary and conclusion
- Conclusions:
- Irritating after 1-hour exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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