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EC number: 233-059-8 | CAS number: 10026-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication, meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Pharmacology and Toxicology of Niobium Chloride
- Author:
- Haley T.J., Komesu N., and Raymond K.
- Year:
- 1 962
- Bibliographic source:
- Toxicology and Applied Pharmacology 4: 385-392
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Niobium pentachloride
- EC Number:
- 233-059-8
- EC Name:
- Niobium pentachloride
- Cas Number:
- 10026-12-7
- Molecular formula:
- Cl5Nb
- IUPAC Name:
- Niobium(V) chloride
- Details on test material:
- - Name of test material (as cited in study report): Niobium pentachloride
- Analytical purity: 99.5%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: abraded and unabraded
- Vehicle:
- not specified
- Controls:
- no
- Observation period:
- 24 and 72 hours, 7 and 14 days
- Number of animals:
- 6
- Details on study design:
- The author mentioned in the publication, that the method of Draize et al. (1944) was used to study skin irritation in rabbits. Niobium pentachloride was directly applied to unabraded and abraded rabbit skin.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- unabraded skin
- Basis:
- mean
- Time point:
- other: 24 h, 72 h
- Score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- unabraded skin
- Basis:
- mean
- Time point:
- other: 24 h, 72 h
- Score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- other: eschar 25-30 mm in diameter
- Basis:
- mean
- Time point:
- other: within 7 days
- Reversibility:
- not reversible
- Remarks on result:
- other: No healing occurred and animals were sacrificed at 14 days
- Irritation parameter:
- overall irritation score
- Remarks:
- on abraded skin
- Basis:
- mean
- Time point:
- other: 24 h, 72 h
- Score:
- 8
- Max. score:
- 8
- Reversibility:
- not reversible
- Remarks on result:
- other: within 7 days perforating ulcers 25-30 mm in diameter with penetration through the skin.
- Irritant / corrosive response data:
- Direct application of niobium pentachloride to unabraded rabbit skin produced an irritation index of 4 within 24 hours for both edema and erythema. These reactions were still present at 72 hours. An eschar 25-30 mm in diameter formed within 7 days with the loss of the skin in the area. Healing did not occur and the animals were sacrificed at 14 days. A severe reaction occurred on abraded skin and resulted in the maximum irritation index of 8 within 24 hours. No change was observed at 72 hours, and within 7 days perforating ulcers 25-30 mm in diameter developed with penetration through the skin to the underlying muscle layers. When healing did not occur at 14 days, the animals were sacrificed.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal irritation/corrosion study according to the method of Draize et al. (1944), the test item is considered to be corrosive to the skin.
- Executive summary:
- In a primary dermal irritation study according to the method of Draize et al., six rabbits were dermally exposed to niobium pentachloride. Animals were observed for 1, 3, 7 and 14 days. On unabraded skin severe erythema and edema were formed within 24 hours continuing to eschars with 24-30 mm in diameter within 7 days that did not heal until day 14. On abraded skin, a maximum irritation index (8/8) was formed within 24 hours. No change was observed at 72 hours and perforating ulcers of 25-30 mm diameter size developed with penetration through the skin to the underlying muscle layers within 7 days. Healing did not occur during the 14 days observation period. Based on these findings, the test item is considered to be corrosive to the skin.
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