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EC number: 205-406-3 | CAS number: 140-26-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short term Fish toxicity:
Based on the Weight of evidence approch for the target substance Phenethyl isovalerate studies are summarized as fallowed :
Based on theEPI Suite ECOSAR version 1.10, the 96 hours LC50 was estimated to be 2.872 mg/L on fish for substance Phenethyl isovalerate with mortality effects.
And in second study which is based on theDanish QSAR database, the short term toxicity in fish for 96 hours LC50 was estimated to be 2.38025 mg/L for substance Phenethyl isovalerate with mortality effects.
But the partition coefficient (log Kow ) value for test substance not≥4 it is found to be in the range 3.71 to 3.9 thus not fulfil the classification criteria of CLP and therefore the target chemical not consider for the aquatic classification.
Above conclusion also support by read across chemical (Cas no.140-11-4) study from peer reviewed journal(U.S.Fish.Wildl.Serv., Sp.Sci.Rep; 124 p., 1963)i.e Short term toxicity study to Cyprinus carpio was carried out for 44 hrs. Test was performed under flow through conditions. After exposure of test animal to different dose conc. i.e, at 68, 130 and 146 mg/l of test chemical benzyl acetate, no effects were observed on mobility of the test animal. Thus, the NOEC value was consider to be 146 mg/l respectively.
Overall all studies concluded that the test substance Phenethyl isovalerate is non toxic to aquatic environment thus not consider for the further classification.
Short term toxicity to aquatic invertebrates
Aim of this study was to assess the short term toxicity of Phenethyl isovalerate
to aquatic invertebrates daphnia magna. Study was performed according to the OECD guideline in a static system for the total exposure period of 48 hrs.
The stock solution 100 g/L was prepared by dissolving yellow powder in reconstituted water. Test solutions of required concentration as were prepared by mixing the stock solution of the test sample with reconstituted test water. It was not possible to test at higher concentration because of limited solubility of tested sample (Changable sentence according to the chemical).0.5,1,2,4,8 mg/Lnominal concentrations were used in the study. Effects on immobilisation were observed for 48 hours. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0.
The median effective concentration (EC50) for the test substance Phenethyl isovalerate
, in Daphnia magna was determined to be 6.4 mg/L on the basis of mobility inhibition effects in a 48 hour study. Based on the EC50 value, indicates that the substance is likely to be hazardous/ non-hazardous to aquatic invertebrates and can be be classified as aquatic chronic 2 category as per the CLP criteria.
Toxicity to aquatic alga and cyanobacteria:
Aim of this study was to evaluate the nature of chemical test chemical when comes in contact with the test organism Desmodesmus subspicatus (previous name: Scenedesmus subspicatus). Test was conducted according to the OECD guideline 201.The test solution 100 mg/l was prepared by dissolving yellow powder in OECD growth medium. Effects on the growth rate of the organism were studied (Changable). Various concentration were used.
With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. Effect on the growth of algae was determine after an exposure period of 72 hrs.
The median effective concentration (ErC50) for the test substance2-phenylethyl 3-methylbutanoate, in algae was determined to be 13.4 mg/L on the basis of growth rate inhibition effects in a 72 hour study. Based on the EC50 value, indicates that the substance is likely to be hazardous to aquatic algae and can be be classified as aquatic chronic 3 category as per the CLP criteria.
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