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EC number: 222-656-9 | CAS number: 3567-66-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity to aquatic invertebrates was estimated by the QSAR prediction done using the Toolbox version 3.3 . EC50 was predicted to be 150.587875366 mg/L in Daphnia magna for 48 hour by QSAR Toolbox version 3.3.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 150.588 mg/L
Additional information
Applying weight of evidence approach to the available predicted and experimental data for the target as well as read-across chemical, the information is summarised as below
Short term toxicity to aquatic invertebrate for D&C Red No. 33 was predicted by QSAR Toolbox version 3.3 . EC50 was predicted to be 150.587875366 mg/L in Daphnia magna for 48 hour by QSAR Toolbox version 3.3. Based on the above mentioned values for the chemical,it is considered that D&C Red No 33 is not hazardous to the aquatic organisms at environmentally relevant concentrations and cannot be classified as per the CLP classification.
Short-term toxicity to aquatic invertebrates was predicted by ECOSAR database LC50 was estimated to be 3943.372 mg/L for 2,7-Naphthalenedisulfonic acid, 5-amino-4-hydroxy-3-(phenylazo)-, disodium salt inDaphnia magna for 48 Hour. Based on the above mentioned values for the chemical, it is considered that 2,7-Naphthalenedisulfonic acid, 5-amino-4-hydroxy-3-(phenylazo)-, disodium salt is not hazardous to the aquatic organisms at environmentally relevant concentrations and can not be classified as per the CLP classification.
In a supporting study by( Luis A.V. de Luna et al.,2014) with similar substance ( CAS NO: 633 -96 -5), Short term toxicity study toDaphnia similiswas carried out for 48 hrs.Neonates of less than 24 h old isolated from Daphnia culture were used for the study.Five test organisms were placed in each screw cap tubes, filled with 10 mL solution, and then incubated at 21±0.3°C in the dark. After 48 h of exposure, the number of immobile organisms was recorded. Jspear software was used to calculate the median 50% immobilization concentration (EC50).Based on immobilization of test organism by test chemical Acid Orange 7, the EC50 value was found to be 87 mg/l alongwith confidence interval (p – 0.05) of 76-99 mg/l.
On the basis of available information for the target as well as read across substance and applying and applying weight of evidence approach, the test substance cannot be considered hazardous to the aquatic organisms at environmentally relevant concentrations and cannot be classified as per the CLP classification.
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