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Diss Factsheets
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EC number: 240-816-6 | CAS number: 16753-62-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a test protocol that is comparable to the appropriate OECD test guideline. The GLP status of the study is uncertain. Read-across is considered to be scientifically valid and reliability 2.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Remarks:
- Although a statement regarding GLP was not available with the study report, it is known that this laboratory conducted studies in compliance with GLP at this time.
- Test type:
- other: LD50
- Limit test:
- no
Test material
- Reference substance name:
- Trimethoxyvinylsilane
- EC Number:
- 220-449-8
- EC Name:
- Trimethoxyvinylsilane
- Cas Number:
- 2768-02-7
- IUPAC Name:
- trimethoxy(vinyl)silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Hilltop Wistar albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200- 300g
Administration / exposure
- Route of administration:
- other: intubation
- Vehicle:
- other: none
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: not reported
- Doses:
- 16.0, 8.0, 4.0, 2.0 and 1.0 ml/kg bw in males; 16.0, 8.0, 4.0 and 2.0 ml/kg bw in females
- No. of animals per sex per dose:
- 45
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Body weights were recorded on days 0, (before dosing), 7 and 14 (prior to termination).
- Necropsy of survivors performed: yes.
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: At necropsy, each animal was subjected to gross pathologic evaluation. - Statistics:
- LD50 with 95% confidence limits; males 7.34 (4.61 to 11.7) ml/kg; females 7.46 (5.16 to 10.8) ml/kg. LD50 slopes; males 3.67, females 4.22.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 7.34 - 7.46 mL/kg bw
- Remarks on result:
- other: Equivalent to 7120 and 7236 mg/kg bw based on relative density of 0.97 g/cm3
- Mortality:
- Deaths occurred at 2.5 hours to 4 days.
- Clinical signs:
- other: Sluggishness, red to brown discharge (around nose, eyes and anus), lacrimation, piloerection, unkempt appearance, prostration, emaciation and unsteady gait were amongst the signs of toxicity observed. Survivors recovered at one to 5 days. With the excepti
- Gross pathology:
- At necropsy, there were several instances of dark red kidney section among victims.
Any other information on results incl. tables
Table 1: Number of animals dead and time range within which mortality occurred.
Dose |
Mortality (# dead/total) |
Time range of deaths (days) |
||
Male |
Female |
Combined |
||
16 |
5/5 |
5/5 |
10/10 |
0 and 1 |
8 |
3/5 |
3/5 |
6/10 |
1,2,3,4 |
4 |
0/5 |
0/5 |
0/10 |
|
2 |
1/5 |
0/5 |
1/10 |
3 |
1 |
0/5 |
0/5 |
0/10 |
|
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 values of 7.34 ml/kg in males and 7.46 ml/kg in females were determined in a reliable study conducted according to a protocol that was comparable to OECD 401. The GLP status of the study is uncertain.
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