Registration Dossier
Registration Dossier
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EC number: 218-542-3 | CAS number: 2177-70-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48 h EC50 = 4.03 mg/L (95% c.i. 3.83 - 4.23 mg/L); OECD Guideline 202; GLP
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.03 mg/L
Additional information
One short-term study in freshwater invertebrates is available for PHMA, which is considered reliable without restriction (Klimisch score 1).
The 48 h acute toxicity of PHMA to Daphnia magna was studied under static-renewal conditions (renewal after 24 h) according to OECD guideline 202 (2004). Daphnids were exposed to control and test chemical at nominal concentration of 0 (control), 0.625, 1.25, 2.50, 5.00 and 10.0 mg/L, corresponding to measured (geometric mean) 0, 0.534, 1.07, 2.13, 4.42 and 8.98 mg/L. Mortality/immobilisation was observed daily.
The 24 h EC50 based on measured (geometric mean) concentrations was 6.94 mg/L (95% c.i. 5.82 - 7.80 mg/L); the 48 h EC50 based on measured (geometric mean) concentrations was 4.03 mg/L (95% c.i.3.83 - 4.23 mg/L).
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