Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 485-300-3 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance (an organic salt) will be absorbed and distributed systemically when administered orally based on histopathological changes in the kidneys of high dose animals. The substance shows an increase of chromosomal aberrations in an in-vitro test without metabolic activation but not with metabolic activation and not in the in-vivo test. Apparently, its metabolites are not active from the genotoxic point of view.
The high water solubility and small moleculare weights of the ions suggest that the substance should be systemically available via pulmonary absorption, but inhalation exposure may be limited by particle size. The low log Pow value and the ionic structure suggest that the substance will not bioaccumulate. Dermal absorption is considered to be very low based on results of dermal toxicity tests (LD50>2000 mg/kg, not irritant to skin (500 mg) nor to eye (100 mg); no sensitisation) indicating, that when applied dermally, the substance is not systemically toxic. The low log Pow value (-2.57 at 22°C) and the ionic structure suggest that the substance is not likely to be sufficiently lipophilic to cross the stratum corneum, therefore dermal absorption is likely to be low.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
