2,4-Pyrimidinediamine, 6-chloro-, 3-oxide

Density

Administrative data

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

-

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

-

Deviations:

no

GLP compliance:

no

Type of method:

pycnometer method

Test material

Test material information

Constituent 1

Reference substance name:

2,4-Diamino-6-chloropyrimidine-3-oxide

EC Number:

609-076-5

Cas Number:

35139-67-4

Molecular formula:

C4H5ClN4O

IUPAC Name:

2,4-Diamino-6-chloropyrimidine-3-oxide

Test material form:

solid

Remarks:

white/beige solid

Specific details on test material used for the study:

- Analytical purity: > 99%- Lot/batch No.: 0160405- Expiration date of the lot/batch: 21/02/2018

Results and discussion

Density

Density 1

Type:

density

Density:

>= 1.584 - <= 1.585 g/cm³

Temp.:

20 °C

Density 2

Key result

Type:

relative density

Density:

ca. 1.585 g/cm³

Temp.:

20 °C

Any other information on results incl. tables

Calculated Values

First Determination				Error rel.	Error abs.
Temperature	19.8	°C			0.1
Density of water	0.998203	g/cm^3		2.00%	0.0002
Volume of Pycnometer	25.5945	cm^3
Density of Replacement Liquid	0.7888
Density of Test Substance	1.5849	g/cm^3		0.0496%	0.0008
Second Determination				Error rel.	Error abs.
Temperature	20.2	°C			0.1
Density of water	0.998203	g/cm^3		2.00%	0.0002
Volume of Pycnometer	25.5948	cm^3
Density of Replacement Liquid	0.7888	g/cm^3
Density of Test Substance	1.5843	g/cm^3		0.0496%	0.0008

rel. = relative; abs. = absolute

 

Presentation of Results

Results of the single determinations with the respective error as well as the mean value and its standard deviation are presented in the following tables:

Results of Single Determinations

Determination	Density in g/cm^3	Error ofDeterm. in g/cm^3
1	1.5849	0.0008
2	1.5843	0.0008

As the third determination confirmed the result of the first determination, the result of the second determination was not used for the calculation of the mean value.

 

Results – Mean Values

Parameter	Value	Unit	Standard Deviation	Relative Standard Deviation
Volume of Pycnometer	25.59	cm^3	0.0002	0.00%
Density of Test Substance	1.5846	g/cm^3	0.0004	0.03%
Density of Test Substance	1584.6	kg/m^3	0.4	0.03%
Relative Density of Test Substance	1.5846		0.0004	0.03%

Final Result

 

Using the pycnometer method, a density of 1.5846 ± 0.0008 g/cm³at 20 ± 0.2 °Cwas measured. This value is the mean of two independent determinations with the maximum error of a single determination.Standard deviation was 0.0004 g/cm³, showing very good correlation of the two determinations.

 

Applicant's summary and conclusion

Conclusions:

Using the pycnometer method, a density of 1.5846 ± 0.0008 g/cm3 at 20 ± 0.2 °C was measured. This value is the mean of two independent determinations with the maxi-mum error of a single determination.Standard deviation was 0.0004 g/cm3, showing very good correlation of the two determinations.

Executive summary:

The relative density of the test item was determined with a not-GLP compliant study following the standard guideline OECD TG 109. Using the pycnometer method, a density of 1.5846 ± 0.0008 g/cm3 at 20 ± 0.2 °C was measured. This value is the mean of two independent determinations with the maxi-mum error of a single determination. Standard deviation was 0.0004 g/cm3, showing very good correlation of the two determinations.