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EC number: 217-049-0 | CAS number: 1730-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Methyl 1,2,3,4-tetrahydro-6-naphthyl ether
- EC Number:
- 217-049-0
- EC Name:
- Methyl 1,2,3,4-tetrahydro-6-naphthyl ether
- Cas Number:
- 1730-48-9
- Molecular formula:
- C11H14O
- IUPAC Name:
- 6-methoxy-1,2,3,4-tetrahydronaphthalene
- Test material form:
- other: liquid
- Details on test material:
- Test item: Methoxy-tetraline
CAS number: 1730-48-9
Batch number: S41214K
Physical state: Liquid
Coluor: Brown
Storage: At a temperature of 15 to 30 °C
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- Source: TOXI-COOP ZRT.
Hygienic level at arrival: SPF
Hygienic level during the test: Good conventional
Number of animals: 28 animals/main test (4 animals/treatment group)
Sex: Female, nulliparous, non-pregnant
Age of animals: Young adult mice; 10-11 weeks old (at start of the main test)
Body weight range at starting: 18.2-22.4 g
Acclimatization time: 7 days
Housing during acclimatization period: Grouped caging in small groups
Housing during the test: Grouped caging (4 animals/cage)
Light: 12 hours daily, from 6.00 a.m. to 6.00 p.m.
Temperature: 22 ± 3 °C
Relative humidity: 30 – 70 %
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Remarks:
- AOO (acetone:olive oil, 4:1) for positive control groups
- Concentration:
- The test item was administered at four different concentrations (100; 50; 25; 10 w/v%) according to the results of the dose range finding test.
- Details on study design:
- Selection of test item concentrations was based on the results of a formulation evaluation and also results of preliminary irritation/toxicity tests to find an appropriate vehicle and the maximum applicable concentration according to the relevant guidelines. Based on the preliminary test results Methoxy-tetraline (CAS No. 1730-48-9) was tested in the LLNA at concentration of 100 % as the undiluted test item and at 50 %, 25 % and 10 % (w/v) concentrations as formulations in Acetone: Olive oil 4:1 (v/v) mixture (AOO). Appropriate positive control (α-Hexylcinnamaldehyde [HCA] in 25 % (w/v) concentration), furthermore two negative control groups dosed with physiological saline (as naive control group), or with the vehicle of the test and positive control groups, respectively, were employed.
The positive control item (25 % (w/v) HCA in AOO) induced the appropriate stimulation over the control, thus confirming the validity of the assay. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- The positive control group animals were treated with 25 % (w/v) HCA solution (dissolved in AOO) concurrent to the test item groups. No mortality, cutaneous reactions or signs of toxicity were observed in the positive control group.
Significant lymphoproliferative response (SI ≥ 3) was noted for HCA (SI = 15.3). The results of the positive control item demonstrated appropriate performance of the test in accordance with the relevant guidelines and confirmed validity of the assay.
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 13.4
- Remarks on result:
- other: Methoxy-tetraline 100% (undiluted)
- Parameter:
- SI
- Value:
- 3.1
- Remarks on result:
- other: Methoxy-tetraline 50 % in DMF
- Parameter:
- SI
- Value:
- 2.5
- Remarks on result:
- other: Methoxy-tetraline 25 % in DMF
- Parameter:
- SI
- Value:
- 1
- Remarks on result:
- other: Methoxy-tetraline 10 % in DMF
- Parameter:
- EC3
- Value:
- 32
- Remarks on result:
- other: based on regression curve
- Parameter:
- EC3
- Value:
- 46
- Remarks on result:
- other: based on dose-response curve
Any other information on results incl. tables
Test Group Name |
Measured DPM/group |
Group* DPM |
DPN (DPM/Node) |
Stimulation Index Values |
Naive control: physiological saline |
2337 |
2314.0 |
289.3 |
1.0 |
Vehicle control for the positive control: AOO |
12954 |
12931.1 |
1616.4 |
1.0 |
Positive control: |
197314 |
197291.0 |
24661.4 |
15.3 |
Methoxy-tetraline |
31146 |
31123.0 |
3890.4 |
13.4 |
Methoxy-tetraline |
39761 |
39738.0 |
4967.3 |
3.1 |
Methoxy-tetraline |
32924 |
32901.0 |
4112.6 |
2.5 |
Methoxy-tetraline |
12844 |
12821.0 |
1602.6 |
1.0 |
*Group DPM = measured DPMgroup- average DPMbackground
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- In conclusion, under the conditions of the present Local Lymph Node Assay, Methoxy-tetraline (CAS No. 1730-48-9) tested at the maximum applicable concentration of 100 % (as the undiluted test item) and at concentrations of 50 %, 25 % and 10 % (w/v) as formulations in an appropriate vehicle (AOO) was shown to have skin sensitization potential. The calculated EC3 values (based on dose-response and regression curve analysis) were 46 % and 32 % (w/v), in this LLNA, respectively. Based on the EC3 values calculated using dose-response and regression curve analysis the test item was considered a weak sensitizer according to the published data.
Using both EC3 values, according to the published data for classification of contact allergens, Methoxy-tetraline (CAS No. 1730-48-9) is ranked among weak sensitizers (10 ≤ EC3 ≤ 100) in this LLNA
According to GHS classification criteria the substance is classified as skin senzitization 1B sub-category.
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