Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-792-9 | CAS number: 28043-10-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study following a method equivalent to a recognised guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- The principles of the method were in accordance with the US 16 CFR 1500.3 definitions.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl 2,6,6-trimethylcyclohex-2-ene-1-carboxylate
- EC Number:
- 248-792-9
- EC Name:
- Methyl 2,6,6-trimethylcyclohex-2-ene-1-carboxylate
- Cas Number:
- 28043-10-9
- Molecular formula:
- C11H18O2
- IUPAC Name:
- methyl 2,6,6-trimethylcyclohex-2-ene-1-carboxylate
- Test material form:
- other: liquid
- Details on test material:
- - Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Recognised animal supplier
- Age at study initiation: Not reported.
- Weight at study initiation: 200 - 300 g
- Fasting period before study: Overnight.
- Housing: Not reported but in compliance with Animal Welfare Act (Pub. L-94-279) 9 CFR Part 3 (USA).
- Diet: rat chow ad libitum
- Water: ad libitum
- Acclimation period: Not reported.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported.
- Humidity (%): Not reported.
- Air changes (per hr): Not reported.
- Photoperiod (hrs dark / hrs light): Not reported.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test material was given orally by syringe and dosing needle. The sample was dosed as supplied.
- Doses:
- 2000, 2510, 3160, 3980, 5000 and 6310 mg/kg bw
- No. of animals per sex per dose:
- Six groups of 10: 5 per sex per dose; 10 total per dose level.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Within first six hours and observations daily for 14 days; body weights before dose and at end of observation period
- Necropsy of survivors performed: Yes.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 700 - 4 900
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 100 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 300 - 4 900
- Mortality:
- 2000 mg/kg bw: No mortalities
2510 mg/kg bw: No mortalities
3160 mg/kg bw: 1 female mortality
3980mg/kg bw: 2 male and 2 female mortalities
5000 mg/kg bw: 4 male and 4 female mortalities
6310 mg/kg bw: Complete mortality. - Clinical signs:
- other: 3160 mg/kg bw: slightly depressed and ruffled after 2 hours. They appeared essentially normal within 24 hours. 3980 mg/kg bw: depressed, ruffled, drooling and dirty after 2-4 hours. They were severely depressed after 6 hours. The surviving animals were in
- Gross pathology:
- No significant findings on necropsy were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study the LD50 was determined to be 4100 mg/kg bw in male/female wistar rats.
- Executive summary:
The GLP study was performed following a method similar to OECD TG 401 to assess the acute oral toxicity potential of the test substance to male/female Wistar rats. The test material was administered as a single oral dose to groups of 5 male and 5 female rats orally, at several dose levels of 2000, 2510, 3160, 3980, 5000 and 6310 mg/kg bodyweight. All animals were observed for a fourteen day period for any signs of toxicity or other effects of treatment. Animals were examined for gross pathology. At 2000 mg/kg bw there was no mortality and no significant systemic toxicity. No remarkable findings were noted on necropsy. Under the conditions of this study the LD50 was determined to be 4100 mg/kg bw (female; C.I. = 3300 - 4900) and 4200 mg/kg bw (male; C.I. = 3700 - 4900).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.