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EC number: 609-869-6 | CAS number: 40834-42-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP / OECD Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Directive 96/54/EC
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 5-hydroxy-4-methyl-2,5-dihydrofuran-2-one
- EC Number:
- 609-869-6
- Cas Number:
- 40834-42-2
- Molecular formula:
- C5 H6 O3
- IUPAC Name:
- 5-hydroxy-4-methyl-2,5-dihydrofuran-2-one
- Details on test material:
- - Name of test material (as cited in study report): Hydroxybutenolid
- Physical state: solid/yellowish
- Analytical purity: 92.7% (potentiometric, titration)
- Lot/batch No.: unknown
- Date of production: March 06, 2000
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar (SPF) / Crl:WI (GLX/BRL/HAN)IGS BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Deutschland, Sandhofer Weg 7, 97633 Sulzfeld.
- Age at study initiation: male animals approx. 8 - 12 weeks; female animals approx. 12 - 18 weeks.
- Weight at study initiation: male animals 208 g; female animals 193 g (200 mg/kg dose group) or 173 g (2 000 mg/kg dose group).
- Fasting period before study: at least 16 h before administration.
- Housing: single housing
- Diet (e.g. ad libitum): Kliba-Labordiät, Provimi Kliba SA, Kaiseraugst, Switzerland
- Water (e.g. ad libitum): tap water
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2 or 20 g/100 ml
- Amount of vehicle (if gavage): 10 ml/kg
- Justification for choice of vehicle: aqueous formulation correspond to the physiological medium.
MAXIMUM DOSE VOLUME APPLIED: approx. 2ml - Doses:
- 2 000 mg/kg b.w. in female animals
200 mg/kg b.w. in male and female animals - No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Body weights: day 0, 7 and 14; signs and symptoms: several times on day of administration, at least once the
following days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, pathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Mortality:
- 3/3 female animals died within 1 hour at the 2000 mg/kg b.w. dose level.
0/3 female animals and 0/3 male animals died at the 200 mg/kg b.w. dose level. - Clinical signs:
- At the 2 000 mg/kg b.w. dose level, clinical signs comprised poor general state, dyspnoea, apathy, abdominal position, ataxia, atonia and paresis. These findings were observed during hour 0 after administration.
No clinical signs and findings werde observed at the 200 mg/kg b.w. dose level. - Body weight:
- The mean body weights in the 200 mg/kg b.w. dose groups increased throughout the study period.
- Gross pathology:
- No macroscopic pathologic abnormalities were noted in the animals that died and in the animals which were examined at the end of the observation period .
Any other information on results incl. tables
Under the conditions of this study the median lethal dose of the test substance after oral administration was found to be greater than 200 mg/kg and less than 2,000 mg/kg body weight for male and female rats.
Applicant's summary and conclusion
- Conclusions:
- According to the results of this study, the substance was classified R22 (EU) and Cat. 4 (H302) accord. to CLP (1272/2008/EC).
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