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Diss Factsheets
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EC number: 601-490-4 | CAS number: 117704-25-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -I: Aqueous Exposure Bioconcentration Fish Test
- Deviations:
- no
- GLP compliance:
- not specified
- Details on sampling:
- Sampling schedule for the definitive test with doramectin:
Uptake phase:
TRR Fish: d 1, 3, 7, 12, 14 and 20 (4 fish each), d 24 (6 fish)
TRR Water: daily (at least 2 samples)
PRP Fish: d 24 (28 fish)
PRP Water: d 24 (4 samples)
Depuration phase:
TRR Fish: d 0.17, 2, 4 and 8 (4 fish each), d 11 (6 fish)
TRR Water d 0–5, 8 and 11 (2 samples each) - Test organisms (species):
- other: zebrafish
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 24 d
- Total depuration duration:
- 11 d
- Nominal and measured concentrations:
- Pre-test: 0.0081 and 0.081 μg/L; definitive test: 0.041 μg/L
- Details on estimation of bioconcentration:
- The verification of the steady state was made based on fish sampled on days 20 and 24 as well as on day 7 (the last sampling day before the overdosage), which had similar accumulation factors.
- Conc. / dose:
- 0.041 mg/L
- Type:
- BCF
- Value:
- 70 L/kg
- Basis:
- whole body d.w.
- Time of plateau:
- 2.88 d
- Calculation basis:
- steady state
- Conc. / dose:
- 0.041 mg/L
- Type:
- BCF
- Value:
- 71 L/kg
- Basis:
- whole body d.w.
- Calculation basis:
- kinetic
- Details on results:
- In the fish exposed to doramectin, no behavioural differences from the control fish were recorded. In all treatments and controls, no mortality was observed.
The doramectin concentrations measured in water were in the range of ± 20% of the mean measured concentration (1215 dpm/mL) on 20 of 23 sampling dates. In individual samples, the measured concentrations were outside of this range (between 56 and 190% of the mean value). On days 8 and 9, the application solution was 4-fold overdosed due to a human failure. This led to in-creased concentrations in water on days 8–10, and, subsequently, in fish on days 12 and 14. These values were excluded from estimation of kinetic parameters. - Conclusions:
- The BCF value of the test substance was estimated as 70-71 L/kg in an OECD 305 study.
Reference
Description of key information
The BCF value of the test substance was estimated as 70-71 L/kg in an OECD 305 study.
Key value for chemical safety assessment
- BCF (aquatic species):
- 70 L/kg ww
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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