Registration Dossier
Registration Dossier
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EC number: 936-349-9 | CAS number: 1312304-36-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate
- Cas Number:
- 1312304-36-1
- Molecular formula:
- C11H12ClN3O4
- IUPAC Name:
- methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CRL (WI) rats
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Remarks:
- PEG 400
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 animals/ 3 animals per group
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The test item did not caused mortality at a dose level of 2000 mg/kg bw.
- Clinical signs:
- other: Clinical signs were observed in animals treated at 2000 mg/kg bw with the test item. These included hunched back (6/6) and incoordination (4/6).
- Gross pathology:
- No macroscopic observations were seen in animals dosed at 2000 mg/kg and terminated on Day 14
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category V
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the acute oral LD50 value of the test item was found to be above 2000 mg/kg bw in female CRL:(WI) rats.
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