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Diss Factsheets
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EC number: 203-079-1 | CAS number: 103-09-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets scientific standards and acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Zur arbeitshygienisch-toxikologischen Beurteilung volkswirtschaftlich bedeutsamer chemischer Substanzen. 4. Kurzmitteilung: Technisches 2-Aethylhexylacetat (Octylacetat).
- Author:
- Schmidt P, Bachmann W
- Year:
- 1 969
- Bibliographic source:
- Z Gesamte Hyg. 15(12): 928-929
Materials and methods
- Principles of method if other than guideline:
- Study to assess the subacute dermal toxicity in rats.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl acetate
- EC Number:
- 203-079-1
- EC Name:
- 2-ethylhexyl acetate
- Cas Number:
- 103-09-3
- Molecular formula:
- C10H20O2
- IUPAC Name:
- 2-ethylhexyl acetate
- Details on test material:
- 2-ethylhexyl acetate, technical purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own breeding (randomized)
- Weight at study initiation: 163 (160-175) g
- Diet Standard diet K (VEG Altglienecke, Germany) ad libitum
- Water ad libitum
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- TEST SITE
- Area of exposure: 3*4 cm, shaved skin
- Type of wrap if used: no wrap used; animals were immobilised during exposure
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 12 days
- Frequency of treatment:
- twice daily for 2 hours on 10 of 12 days
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0, ca. 1070 mg/kg bw/day
Basis:
nominal per unit body weight
- Remarks:
- Doses / Concentrations:
0, ca. 535 mg/kg bw/treatment
Basis:
nominal per unit body weight
- Remarks:
- Doses / Concentrations:
0, 0.1 ml/animal/ treatment
Basis:
nominal per unit area
- No. of animals per sex per dose:
- treatment: 12 females; control: 6 females
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Post-exposure period: 28 days
Examinations
- Observations and examinations performed and frequency:
- The condition of the skin was evaluated, the body weight of the animals was juged twice a week in the beginning, later on once a week.
- Sacrifice and pathology:
- At the end of the 28 days post exposure, the animals were sacrificed and the organs examined macroscopically.
Results and discussion
Results of examinations
- Details on results:
- No significant differences were observed between treated and control animals at any time.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Remarks:
- systemic
- Effect level:
- >= 1 070 mg/kg bw/day (nominal)
- Sex:
- female
- Basis for effect level:
- other: no effects
- Dose descriptor:
- NOAEL
- Remarks:
- local
- Effect level:
- >= 1 070 mg/kg bw/day (nominal)
- Sex:
- female
- Basis for effect level:
- other: no effects
- Dose descriptor:
- NOAEL
- Remarks:
- local
- Effect level:
- >= 14.5 mg/cm² per day (nominal)
- Sex:
- female
- Basis for effect level:
- other: no effects
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.