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EC number: 210-568-3 | CAS number: 618-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- Data is from study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Assesment of a possible irritating or corrosive potential of the skin
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-nitroisophthalic acid
- EC Number:
- 210-568-3
- EC Name:
- 5-nitroisophthalic acid
- Cas Number:
- 618-88-2
- Molecular formula:
- C8H5NO6
- IUPAC Name:
- 5-nitroisophthalic acid
- Test material form:
- solid
- Details on test material:
- IUPAC name: 5-Nitrobenzene-1,3-dicarboxylic acid
Mol. formula: C8H5NO6
Molecular Weight: 211.128 gm/mol
Smiles: OC(=O)c1cc(cc(c1)[N+](=O)[O-])C(=O)O
InChI: InChI=1S/C8H5NO6/c10-7(11)4-1-5(8(12)13)3-6(2-4)9(14)15/h1-3H,(H,10,11)(H,12,13)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: Male: 2.79 gm
Female: 2.85 gm
- Housing: Cage made of stainless steel with wire mesh walk floors. (Floor area: 40cm x 51cm)
- Diet (e.g. ad libitum):
- Water : 250 ml tap water/animal/day
- Acclimation period: Atleast 8 days before the study. Same housing conditions as during the study.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24°C
- Humidity (%): 30-70%
- Air changes (per hr): Fully air conditioned
- Photoperiod (hrs dark / hrs light): 12h/12h (6.00-18.00 hours/18.00-6.00 hours)
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 50% aqueous formulation (W/W)
THE TEST PATCH (2.5 CM X 2.5 CM) IS COVEREO WITH AN ABOUT 0.5 MM LAYER OF THE 50% SUSPENSION (THUS ABOUT 0.5 G OF THE SUSPENSION IS APPLIED; BECAUSE OF THE NATURAL MOISTURE OF TNE SKIN, DISTILLED WATER IS USED TO PREPARE THE SUSPENSIONS SO THAT THE TEST CAN BE CARRIED OUT UNDER AS PHYSIOLOGICAL CONDITIONS AS POSSIBLE. - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 30-60 minutes after the removal of the test patch.
24, 48 and 72 hours after the beginning of the application - Number of animals:
- Total: 3
Male: 1
Female: 2 - Details on study design:
- TEST SITE
- Area of exposure: Upper third of the back or flanks
- % coverage: (2.5cm x 2.5 cm)
- Type of wrap if used: Porous dressing (Four layers of absorbent gauze+porous bandage)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes, at the end of the exposure period with Lutrol and Lutrol/water (1:1)
- Time after start of exposure: 72 hrs
OBSERVATION TIME POINTS
(indicate if minutes, hours or days): 30-60 minutes after removal of the test patches and 24, 48 and 72 hours after the beginning of the application.
SCORING SYSTEM:
- Method of calculation:
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation potential observed
- Other effects:
- No other effects observed.
Any other information on results incl. tables
Table: Body weight data
Animal |
1 |
2 |
3 |
Animal no. |
0075 |
0100 |
0085 |
Body weight (kg) |
2.79 |
2.72 |
2.97 |
Sex |
Male |
Female |
Female |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- No clinical signs of Erythema and Edema were observed during the observation period, thus indicating that the test chemical is not irritating to skin of rabbits.
- Executive summary:
Acute skin irritation test, according to OECD guidelines 404 for testing of chemicals, was conducted on the intact dorsal skin of the Vienna white rabbit for test substance. 50% aqueous solution of the test substance was applied in an area of 2.5 cm x 2.5cm on the upper third of the back of the test animals. The test animals were exposed for 4 hours and readings were taken 30 -60 minutes after the removal of test patches and 24 H, 48 H. 72 H, after the beginning of application. Untreated skin sites of the same animal were treated as negative control. Observations were made for appearance of any symptoms of Erythema and Edema on the tested skin sites. However, none of the observations taken at different intervals showed any clinical signs of Erythema and Edema. Based on the results, the test substance was considered as not irritating to skin.
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