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Diss Factsheets
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EC number: 211-162-9 | CAS number: 631-61-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: A scientific study. No GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
- Principles of method if other than guideline:
- From 2 to 4.5 months of age, 80 crossbred gilts were reared in a conventional grower unit where they were naturally exposed to mycoplasmal and bacterial pathogens that cause pneumonia and atrophic rhinitis. At 4.5 months of age, gilts were moved to environmentally regulated rooms (4.9 x 7.3 m) and assigned at random to 1 of 2 treatment groups: low aerial concentration of ammonia (4 to 12 ppm; mean, 7 ppm) or moderate aerial concentration of ammonia (26 to 45 ppm, mean, 35 ppm). Low concentration of ammonia was obtained by flushing of manure pits weekly, whereas moderate concentration of ammonia was maintained by adding anhydrous ammonia to manure pits that were not flushed. Gilts were weighed biweekly. Mean daily gain (MDG) was less (P < 0.01) for gilts exposed to moderate concentration of ammonia than for gilts exposed to low concentration of ammonia after 2 weeks in their respective environments. By 4 and 6 weeks, however, MDG was similar between the 2 treatment groups. After 6 weeks in these environments, 20 gilts from each treatment group were slaughtered, and prevalence and severity of lung lesions and snout grades were determined.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Ammonia, anhydrous
- EC Number:
- 231-635-3
- EC Name:
- Ammonia, anhydrous
- Cas Number:
- 7664-41-7
- IUPAC Name:
- ammonia
- Details on test material:
- - Name of test material (as cited in study report): Ammonia anhydrous
Constituent 1
Test animals
- Species:
- pig
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4.5 wks
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- whole body
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- female pigs were continuously exposured to 7 and 35 ppm ammonia for 6 weeks before breeding until 30 day of gestation.
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
7 during 6 weeks
Basis:
other: by inhalation
- Remarks:
- Doses / Concentrations:
35 dirung 6 weeks
Basis:
other: by inhalation
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- effects observed, treatment-related
Reproductive function / performance (P0)
- Reproductive performance:
- effects observed, treatment-related
Effect levels (P0)
- Dose descriptor:
- NOAEC
- Effect level:
- 35 ppm (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: (reproductive effects)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
No statistically significant differences were noted in ovarian or uterine weights of pigs exposed to about 7 and 35 ppm ammonia for 6 weeks. Female pigs were continuously exposured to 7 and 35 ppm ammonia for 6 weeks before breeding until 30 day of gestation had no statistically significant differences in age at puberty, number of live fetuses, or -to-corpus luteum ration compared to pigs exposed only to 7 ppm. No unexposed controls were included in the study.
Applicant's summary and conclusion
- Conclusions:
- No statistically significant differences were noted in ovarian or uterine weights of pigs exposed to about 7 and 35 ppm ammonia for 6 weeks. Female pigs were continuously exposured to 7 and 35 ppm ammonia for 6 weeks before breeding until 30 day of gestation had no statistically significant differences in age at puberty, number of live fetuses, or -to-corpus luteum ration compared to pigs exposed only to 7 ppm. No unexposed controls were included in the study.
- Executive summary:
No statistically significant differences were noted in ovarian or uterine weights of pigs exposed to about 7 and 35 ppm ammonia for 6 weeks. Female pigs were continuously exposured to 7 and 35 ppm ammonia for 6 weeks before breeding until 30 day of gestation had no statistically significant differences in age at puberty, number of live fetuses, or -to-corpus luteum ration compared to pigs exposed only to 7 ppm. No unexposed controls were included in the study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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