Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.1 mg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
1 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.01 mg/L
Assessment factor:
10 000
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
1 000 mg/L
Assessment factor:
1
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.238 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.024 mg/kg sediment dw

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.025 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
PNEC oral
PNEC value:
313 mg/kg food
Assessment factor:
3 000

Additional information

Based on a combination of short term test data, read-across with structural analogues and quantitative structure activity relationship analysis (QSARs), dipropylene glycol presents a low hazard concern for the aquatic environment. The short-term toxicity values used in the assessement are the 96-h LC50 of >1000 mg/l for fish (based on read-across with structural analogues), the 48-h EC50 of >100 mg/l for invertebrates, the 72-h EC50 and 72-h NOEC of >100 mg/l for algae. The 18-h EC10 of dipropylene glycol to Pseudomonas putida was 1000 mg/l. Although chronic test data are not available, QSAR predictions suggest that dipropylene glycol will not cause chronic toxicity to aquatic organisms. Additional testing seems therefore not necessary.

Conclusion on classification

The lowest acute aquatic toxicity value is 100 mg/l for the freshwater invertebrate Daphnia magna and for the freshwater algae Desmodesmus subspicatus. A 96h LC50 of > 1000 mg/l to fish can be assumed based on read-across with structural analogues..

Based on the result of the octanol/water partition coefficient (Log Kow of -0.64) and from results of the bioaccumulation study with carp species dipropylene glycol is not expected to significantly accumulate in aquatic organisms (BCF 0.3 to 4.6 l/kg). Furthermore, the substance is ready biodegradable. For these reasons, dipropylene glycol is not classified in Annex I of Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.