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Diss Factsheets
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EC number: 215-607-8 | CAS number: 1333-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15th-18th February 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Proprietary guideline-compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Department of Transport
- Deviations:
- no
- Principles of method if other than guideline:
- Corrosivity screening test in the rabbit in vivo
- GLP compliance:
- no
- Remarks:
- Pre-GLP study
Test material
- Reference substance name:
- Chromic acid mixture
- IUPAC Name:
- Chromic acid mixture
- Reference substance name:
- chromium (VI) trioxide
- IUPAC Name:
- chromium (VI) trioxide
- Details on test material:
- Red powder: no further details provided. The test material was a mixture of chromium (VI) trioxide from different sources.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Controls:
- not required
- Amount / concentration applied:
- 0.5 g, moistened with 0.5 ml saline
- Duration of treatment / exposure:
- Up to 30 minutes
- Observation period:
- Up to 1 hour
- Number of animals:
- Two
- Details on study design:
- Two animals were exposed for three minutes and observed at regular intervals for corrosive effects.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not reversible
- Remarks on result:
- other: signs of local tissue destruction
- Irritant / corrosive response data:
- Signs in both animals indicate local tissue destruction, which was confirmed by histopathology.
- Other effects:
- Histopathology showed coagulative necrosis of the epidermis and the outer dermis, with epidermal sloughing and capillary congestion.
Any other information on results incl. tables
Brown discoloration of the application site in the first animal after 3 minutes prevented the assessment of erythema; slight oedema (Grade 2) was apparent at this stage. Similar findings were noted at 15 minutes (following replacement of the patch). At 30 minutes Stage 3 oedema was observed and the animal showed signs of pain. The skin was noted to be hard and leathery. The animal was sacrificed at this point. The second animal showed signs of pain within 30 seconds of administration. Scoring of erythema was not possible after 3 minutes due to brown discoloration of the skin: the patch was not replaced at this point. Slight (Grade 2) oedema was apparent and the skin was hard. Moderate (Grade 3) oedema was seen at 30 and 60 minutes, at which point the animal was sacrificed.
Applicant's summary and conclusion
- Interpretation of results:
- other: corrosive based on EU GHS criteria
- Conclusions:
- The results of the study show that chromium (VI) trioxide is corrosive to skin.
- Executive summary:
0.5 g chromic acid (moistened with 0.5 ml physiological saline) was applied under occlusive conditions to the shorn dorsal skin of two rabbits. The application time in the first animal was 30 minutes; observations were made at up to 30 minutes, when the animal was sacrificed for humane reasons. Application time in the second animal was 3 minutes; observations were made for up to 1 hour, when the animal was sacrificed for humane reasons. In both animals, the skin at the application site appeared hard and brown, preventing the assessment of erythema. Oedema and pain were observed in both animals from early timepoints. Histopathology of skin at the application site confirmed a corrosive effect.
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