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Diss Factsheets
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EC number: 217-204-2 | CAS number: 1774-47-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented study according to international accepted guidelines and GLP compliant.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Trimethyloxosulphonium iodide
- EC Number:
- 217-204-2
- EC Name:
- Trimethyloxosulphonium iodide
- Cas Number:
- 1774-47-6
- Molecular formula:
- C3H9OS.I
- IUPAC Name:
- trimethyl(oxo)-λ⁶-sulfanylium iodide
- Test material form:
- solid: crystalline
- Details on test material:
- Test item: Trimethylsulfoxonium Iodide (CAS 1774-47-6)
Batch No.: 20130228 (0056D53)
Physical state: solid, crystalline powder
Colour: white or light-yellow
Content (Chemical Titration): 99.66 %
Storage: on cool and dry place, protected from light
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Species and strain: New Zealand white rabbit
Source: S & K-LAP Kft.
Number of animal: 3 males
Age of animals: adult rabbits, 17 weeks old
Hygienic level during the study: good conventional
Animal health: Only animals in acceptable health condition were used for the test.
Housing: Animals were housed individually in metal cage.
Light: 12 hours daily, from 6.00 a.m. to 6.00 p.m.
Temperature: 20 ± 3 °C
Relative humidity: 30-70 %
Ventilation: 10-15 air exchanges/hour by central air-condition system
The environmental parameters were recorded daily during the study.
Before housing the animals the microbiological status of the room was checked.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The contralateral eye served as control
- Amount / concentration applied:
- 0.1 g of the test item was used for the study in undiluted state, as a single dose.
- Duration of treatment / exposure:
- The eyes of the test animals were not washed out 24 hour after test item application, because the test item had been removed from the eye of test animal by physiological mechanisms.
- Observation period (in vivo):
- The eyes were examined at 1, 24, 48 and 72 hours then 1 week after the application.
- Number of animals or in vitro replicates:
- 3 male
- Details on study design:
- In the first step an initial test was performed using one animal. The test item was placed into the conjunctival sac of the left eye. The eyelids were held closed gently for about one second to prevent any loss of the test item. The contralateral eye served as control. In the initial test slight irritant effect was observed 24 hours after treatment. The confirmatory test was conducted using a second animal. Slight irritant effects were observed 24 hour after treatment. Following treatment of the second animal, the second confirmatory test was conducted using a third animal.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- (opacity)
- Basis:
- mean
- Time point:
- other: 24h; 48h; 72h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- other: redness (conjunctival)
- Basis:
- mean
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0.66 - 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 1 week
- Irritation parameter:
- chemosis score
- Remarks:
- (conjunctival)
- Basis:
- mean
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0 - 0.66
- Max. score:
- 0.66
- Reversibility:
- fully reversible within: 1 week
- Irritation parameter:
- other: conjunctival discharge
- Basis:
- mean
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0 - 0.33
- Max. score:
- 0.33
- Reversibility:
- fully reversible within: 1 week
- Irritant / corrosive response data:
- Treated and control eyes were examined at 1, 24, 48 and 72 hours then 1 week after the application.
One hour after treatment some hyperemic blood vessels of the conjunctivae were observed in all animals. The swelling of the conjunctivae was different from normal in two animals. 24 hours after treatment some hyperemic blood vessels of the conjunctivae were observed in all animals. The swelling of the conjunctivae was different from normal in one animal. 48 hours after treatment some hyperemic blood vessels of the conjunctivae were observed in all animals. The swelling and the amount of discharge of the conjunctivae were different from normal in one animal. 72 hours after treatment some hyperemic blood vessels of the conjunctivae were observed in two animals. One animal became free of symptoms. 1 week after treatment all animals were free of symptoms, so the study was finished. During the study the control eyes of animals were symptom-free.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The test item applied to the rabbits' eye mucosa, caused slight conjunctival irritant effects, fully reversible within 1 week. No systemic toxicity was observed on the day of the treatment and during the 1-week observation period. The test item should be classified into GHS Category 2B.
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