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EC number: 618-939-5 | CAS number: 933999-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
- GLP compliance:
- yes
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2-({[6-({1-chloro-3-[(oxiran-2-yl)methoxy]propan-2-yl}oxy)hexyl]oxy}methyl)oxirane; 2-[({6-[(oxiran-2-yl)methoxy]hexyl}oxy)methyl]oxirane; 3-chloro-2-({6-[(oxiran-2-yl)methoxy]hexyl}oxy)propan-1-ol; 6-[(oxiran-2-yl)methoxy]hexan-1-ol
- EC Number:
- 618-939-5
- Cas Number:
- 933999-84-9
- Molecular formula:
- C6H14O2 + C3H5ClO
- IUPAC Name:
- 2-({[6-({1-chloro-3-[(oxiran-2-yl)methoxy]propan-2-yl}oxy)hexyl]oxy}methyl)oxirane; 2-[({6-[(oxiran-2-yl)methoxy]hexyl}oxy)methyl]oxirane; 3-chloro-2-({6-[(oxiran-2-yl)methoxy]hexyl}oxy)propan-1-ol; 6-[(oxiran-2-yl)methoxy]hexan-1-ol
- Details on test material:
- As per IUCLID5 Sections 1.1. - 1.4.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Sprague-Dawley rats 6 to 8 weeks of age were acquired from Charles River UK Limited, Margate, Kent. the animals were housed in polyproylene cages and allowed free access to feed (Labsure LAD 1) and tap water. The animal holding room temperature was 18 - 24 degrees C and the relatuve humidity was 35 - 65% during the study.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The rats were exposed continously by whole body in inhalation chambers for 4 hr to the test atmosphere containing vapor and droplets of the test substance. A vapor generator was used to supply test substance to the inhalation chamber. 1,6-Hexanediol Diglycidylether (HDDGE) was supplied to the vapor generator by means of a syringe driven by a syringe pump. Clean dried air at approximately 50 C was supplied under pressure to the vapor generator at a flow rate of approximately 25 liters per minute. The animals were exposed to this vapor of HDDGE for 4 hr and then returned to eteir cages. Test substance concentration was monitored by withdrawing five samples from the inhalation chamber followed by GC analysis.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0.035 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- Five animals of each sex were exposed to a concentration of 1,6-Hexanediol Diglycidylether (HDDGE) of approximately 35 mg/m3 (3.7 ppm) for 4 hr. The control group was exposed to air only. The animals were observed continously during exposure for clinical signs and at least twice daily during the 14-day observation period. Body weights were taken daily and feed and water consumption calculated on a daily basis. Following sacrifice, the animals were subjected to a detailed macroscopic examination. The lungs were removed, dissected free of surronding tissue and weighted.
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: NOEC
- Effect level:
- 0.035 mg/L air (analytical)
- Exp. duration:
- 4 h
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: No abnormalities.
- Body weight:
- No adverse effects of exposure.
- Gross pathology:
- No abnormalities that were considered to be of toxicological significance.
Any other information on results incl. tables
Sample |
Time |
Concentration in air (mg/L) |
2.1 2.2 2.3 2.4 2.5 |
0h : 30m 1h : 00m 2h : 00m 3h : 00m 3h : 45m |
0.042 0.036 0.027 0.026 0.044 |
Mean |
0.035 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The highest attainable concentration of HDDGE, 0.035 mg/l of air (3.7 ppm), was not toxic to rats after a single, 4-hour, whole-body exposure.
- Executive summary:
1,6-Hexanediol Diglycidylether (HDDGE) was accessed for acute inhalation toxicity potential by an O.E.C.D. 433 Testing Guideline study conducted with GLP compliance. The animals were exposed by whole body inhalation to primarily vapor phase HDDGE. The highest attainable concentration of HDDGE, 0.035 mg/l of air (3.7 ppm), induced no mortalities and was not toxic to rats after a single, 4-hour, whole-body exposure.
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