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EC number: 204-857-3 | CAS number: 127-68-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Weight of evidence
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Weight of evidence
- Title:
- Toxicokinetics
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 013
- Bibliographic source:
- Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium 3-nitrobenzenesulphonate
- EC Number:
- 204-857-3
- EC Name:
- Sodium 3-nitrobenzenesulphonate
- Cas Number:
- 127-68-4
- Molecular formula:
- C6H5NO5S.Na
- IUPAC Name:
- sodium 3-nitrobenzenesulphonate
- Test material form:
- solid
- Details on test material:
- - Name of test material : Sodium 3-nitrobenzenesulphonate
- Molecular formula : C6H4NNaO5S
- Molecular weight : 225.1556 g/mol
- Smiles notation : c1(cc(ccc1)[N+](=O)[O-])S(=O)(=O)[O-].[Na+]
- InChl : 1S/C6H5NO5S.Na/c8-7(9)5-2-1-3-6(4-5)13(10,11)12;/h1-4H,(H,10,11,12);/q;+1/p-1
- Substance type : Organic
- Physical state : Solid
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- other: unspecified
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: estimation
- Vehicle:
- unchanged (no vehicle)
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The absorption possibility of sodium 3-nitrobenzenesulphonate particles through the inhalation route is unlikely since the chemical has a particle size distribtuion that ranges from 75 to 600 micrometer. This does not constitute inhalable particulate size which ranges from 2.5 to less than 10 micrometer. However, the vapour pressure of the chemical can result in some exposure by the inhalation route.
The absorption through the oral route will also be low given the use of this chemical as an antireduction agent with use in chemical, electrical/electronics, photographic, and textile processing industries. Also, absorption through the dermal route is expected to be moderate (Predicted data). - Details on distribution in tissues:
- The absorbed sodium 3-nitrobenzenesulphonate is expected to be distributed through the blood and lipids to various parts of the body given its solubility in water as well as organic solvents. However, it shall not be accumulated in the body due to the fact that the substance has low BCF value (3.2). After distribution, if the chemical is not accumulated in the body it is most likely to be excreted out of the living system.
- Details on excretion:
- It is expected that sodium 3-nitrobenzenesulphonate shall be excreted unchanged (given the Log Kow value of - 1.292) through urine and feaces. The molecular weight of the chemical is 225.15 which is also suggestive of excretion via the urinary route.
Metabolite characterisation studies
- Metabolites identified:
- no
- Details on metabolites:
- There is no information available on the metabolism of sodium 3-nitrobenzenesulphonate in humans and animals. However, considering the Log Kow value of - 1.292, it can be assumed that the chemical shall not be bio-available and therefore unlikely to be metabolized.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: Bio-accumulation potential of sodium 3-nitrobenzenesulphonate appears to be low
In the absence of toxico-kinetic data for humans and animals for the chemical sodium 3-nitrobenzenesulphonate; certain physico-chemical and other properties that shall influence the absorption, distribution, bio-transformation and elimination out of the living systems have been considered for evaluating the toxico-kinetics.
From the available information, it appears that the bioaccumulation potential of sodium 3-nitrobenzenesulphonate is expected to be low. - Executive summary:
Given the lack of data on the toxico-kinetics ofsodium 3-nitrobenzenesulphonate; the toxico-kinetic behaviour has been predicted considering the physico-chemical and other properties that shall influence the absorption, distribution, bio-transformation and elimination out of the living systems. The key properties have been mentioned in the table below
Property
127-68-4
(sodium 3-nitrobenzenesulphonate)
Physical state
Solid
Vapor Pressure (hPa at 25oC)
10.3 Pa at 25oC
Water Solubility (mg/L)
4200 mg/L at 23oC
Log Kow
-1.292 at 23oC
Rapid Biodegradation
Readily bio-degradable in water
Bio-concentration factor BCF
3.2
Dermal absorption mg/cm2/event (Source: DEPA)
0.005 (moderate)
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