Registration Dossier
Registration Dossier
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EC number: 469-910-7 | CAS number: 847842-48-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Results based on nominal concentrations as mg/L of abacavir sulphate:
Based on areas under the growth curve the results obtained at 72 hours were:
No observed effect (P=0.05) concentration (NOEC) = 30 mg L-1
Lowest observed effect (P=0.05) concentration (LOEC) = 60 mg L-1
Median effective concentration, biomass (EbC50) = 57.4 mg L-1
95% confidence limits = 56.9 - 57.8 mg L-1
Based on logarithmic growth rate over the test period, the results obtained were:
No observed effect (P=0.05) concentration (NOEC) = 30 mg L-1
Lowest observed effect (P=0.05) concentration (LOEC) = 60 mg L-1
Median effective concentration, growth rate (ErC50) = 85.4 mg L-1
95% confidence limits = 79.4 - 91.3 mg L-1
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 57.4 mg/L
- EC10 or NOEC for freshwater algae:
- 30 mg/L
Additional information
The study was carried out on one of the analogue materials. The analogue is considered to be sufficiently similar to the substance of interest (please see attached data matrix and justification in Section 13 for additional details) for it to be used for the purposes of health and environment risk assessments.
A study to assess the toxicity of the test material to the green algaSelenastrum capricornutumaccording to OECD guideline 201, Alga, Growth Inhibition test.
Test concentrations: Culture medium control and nominal concentrations of 7.5, 15, 30, 60 and 120 mg L-1.
Length of test: 72 hours, static.
Nominal test temperature: 24 ± 2°C
Results based on nominal concentrations as mg/L-1of abacavir sulphate:
Based on areas under the growth curve the results obtained at 72 hours were:
No observed effect (P=0.05) concentration (NOEC) = 30 mg L-1
Lowest observed effect (P=0.05) concentration (LOEC) = 60 mg L-1
Median effective concentration, biomass (EbC50) = 57.4 mg L-1
95% confidence limits = 56.9 - 57.8 mg L-1
Based on logarithmic growth rate over the test period, the results obtained were:
No observed effect (P=0.05) concentration (NOEC) = 30 mg L-1
Lowest observed effect (P=0.05) concentration (LOEC) = 60 mg L-1
Median effective concentration, growth rate (ErC50) = 85.4 mg L-1
95% confidence limits = 79.4 - 91.3 mg L-1
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