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EC number: 203-786-5 | CAS number: 110-63-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well-documented report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Butane-1,4-diol
- EC Number:
- 203-786-5
- EC Name:
- Butane-1,4-diol
- Cas Number:
- 110-63-4
- Molecular formula:
- C4H10O2
- IUPAC Name:
- butane-1,4-diol
- Details on test material:
- - Name of test material (as cited in study report): 1.4-Butanediol
- Physical state: colorless liquid
- Analytical purity: 99.3%
- Impurities (identity and concentrations): 2-Methylbutandiol 1,4: 0.4%; Methylpentandiol: 0.2%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Sulzfeld/Germany
- Age at study initiation: 12 weeks
- Weight at study initiation: male: 204 g (mean); female: 180 g (mean)
- Housing: 5 animals per cage in V-II-A stainless steel wire mesh cages (supplied by Becker and Co., Castrop-Rauxel/Germany)
- Diet: SSNIFF R, Ssniff Versuchstierdiaeten, Soest/Germany
- Water: Fully demineralized water each workday, ad libitum; tap water on public holidays, ad libitum.
- Acclimation period: Acclimatization in the animal care unit for at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 26 °C
- Humidity (%): 45 - 75 %
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25, 20, 15, 13, 10 %
MAXIMUM DOSE VOLUME APPLIED: 10 ml - Doses:
- 1000, 1300, 1500, 2000, 2500 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: <15 min, 15 min, 30 min, 1 h, 2 h, 4 h and 5 h after administration of test substance and then once each workday. Check for moribund and dead animals twice each workday and once daily at weekends and on public holidays.
- Frequency of weighing: days 0, 3, 7, 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 500 mg/kg bw
- 95% CL:
- 1 360 - 1 680
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 670 mg/kg bw
- 95% CL:
- 1 420 - 2 040
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 350 mg/kg bw
- Mortality:
- see details in remarks on results.
- Clinical signs:
- other: Male animals: dyspnea, apathy, abnormal position, staggering, atony, unusual pain reflex, unusual cornea reflex, narcotic-like state, tremor, scrubby fur, exsiccosis, exophthalamus, poor general state. Female animals: dyspnea, apathy, abnormal position,
- Gross pathology:
- Animals that died: general congestive hyperemia.
Sacrificed animals: nothing abnormal detected.
Any other information on results incl. tables
Mortality:
Dose (mg/kg bw) |
1 h |
24 h |
48 h |
7 days |
14 days |
|||||
|
male |
female |
male |
female |
male |
female |
male |
female |
male |
female |
2500 |
0 |
0 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
2000 |
0 |
0 |
5 |
4 |
5 |
4 |
5 |
4 |
5 |
4 |
1500 |
0 |
0 |
5 |
2 |
5 |
2 |
5 |
2 |
5 |
2 |
1300 |
0 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
1000 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Mean Body Weights:
Dose (mg/kg bw) |
day 0 |
day 3 |
day 7 |
day 13 |
||||
|
male |
female |
male |
female |
male |
female |
male |
female |
2500 |
200 |
180 |
- |
- |
- |
- |
- |
- |
2000 |
170 |
180 |
- |
200 |
- |
220 |
- |
229 |
1500 |
210 |
180 |
- |
200 |
- |
217 |
- |
222 |
1300 |
220 |
180 |
253 |
205 |
288 |
214 |
323 |
218 |
1000 |
220 |
180 |
238 |
205 |
277 |
217 |
327 |
228 |
The application of the test substance caused systemic toxicity, including mortality, in a dose dependent manner.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 value for 1,4-Butanediol administered to male and female Sprague-Dawley rats is 1500 mg/kg bw. Administration of the substance produced systemic toxicity in a dose-dependent manner.
- Executive summary:
1,4 -Butanediol was administered at 1000, 1300, 1500, 2000, and 2500 mg/kg bw in an aqueous solution to a test group of male and female Sprague-Dawly rats consisting of 5 animals/sex by single gavage application. The animals were observed for mortality and for clinical symptoms (dyspnea, apathy, abnormal position, staggering, atony, unusual pain reflex, unusual cornea reflex, narcotic-like state, tremor, scrubby fur, exsiccosis, exophthalamus, poor general state) of toxicity. They were weighed prior treatment and thereafter, day 3, day 7 and day 13 post-treatment. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The LD50 value was estimated to 1500 mg/kg bw on the basis of the observed mortalities.
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