Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-186-4 | CAS number: 12125-02-9
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: human medical data
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliability adopted form SIDS
Data source
Reference
- Reference Type:
- publication
- Title:
- Ammonium chloride poisoning in chronic renal disease.
- Author:
- Levene D.L. and Knight A.,
- Year:
- 1 974
- Bibliographic source:
- CAN Med. Assio. Journal, 111, 335-338 (1974)
Materials and methods
- Study type:
- human medical data
- Endpoint addressed:
- repeated dose toxicity: oral
- Principles of method if other than guideline:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Ammonium chloride
- EC Number:
- 235-186-4
- EC Name:
- Ammonium chloride
- Cas Number:
- 12125-02-9
- Molecular formula:
- ClH4N
- IUPAC Name:
- ammonium chloride
Constituent 1
Method
- Type of population:
- general
- Details on study design:
- Number of subjects exposed: 1
- Sex: female
- Age: 58 years
- Race: no data
- Demographic information: no data
- Known diseases: long history of renal stone disease and urinary tract infection
Results and discussion
- Results:
- Laboratory data confirmed profound metabolic acidosis. Unduly large quantities of bicarbonate and potassium were required for correction of the deficits. The combination of impaired renal function and effective hydrogen ion loading resulted in profound systemic acidosis.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
