Registration Dossier
Registration Dossier
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EC number: 203-726-8 | CAS number: 109-99-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a key study conducted essentially according to OECD Guideline 429, tetrahydrofuran did not produce a three-fold or greater response in trititated thymidine incorporation and was thus rated negative in the mouse local lymph node assay (LLNA) whan administered neat (50 microliters/mouse) on each of 3 successive days. In supporting LLNA studies in mice, tetrahydrofuran was used as a vehicle control in 2 studies. Results, as dpm/node, were 805.28 and 745.21 dpm/node, respectively. Based on control data from the testing laboratory, these values were within historical control ranges. Tetrahydrofuran was judged to be a nonsensitiser in this study.
Migrated from Short description of key information:
Tetrahydrofuran was found to be negative when tested with the murine Local Lymph Node Assay (LLNA), and was used as a solvent control in at least two additional LLNA studies, again with no evidence of sensitising properties.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
Tetrahydrofuran has not been specifically tested for respiratory sensitisation, but as multiple studies on skin sensitisation have been negative and the compound contains no functional groups of concern, THF is not expected to present any respiratory sensitisation hazard.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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