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EC number: 273-760-6 | CAS number: 69012-63-1 By-product of refining of zinc ores consisting primarily of zinc, lead and iron.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not applicable
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented and scientifically good . Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute inhalation toxicity
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Flue dust, zinc-refining
- EC Number:
- 273-760-6
- EC Name:
- Flue dust, zinc-refining
- Cas Number:
- 69012-63-1
- Molecular formula:
- Not applicable - UVCB
- IUPAC Name:
- Zinc oxide enriched flue dust
- Details on test material:
- name of test substance: probe B (= Wälzoxid)
description: grey dust
batch number: feb '99
purity: unknown
aggregate state at room temp: solid
density (g/cm3 at 20°C): +/-5
solubility of the test item: considered to be stable under the conditions specified below
expiry date: dec 2000
storage conditions: in original , tightly sealed container, at room temp (20-25°C) protected from direct sunlight
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: RCC Ltd Biotechnology and Animal Breeding Division CH-4414 Füllinsdorf/Switserland
- Age at study initiation: 10 weeks for males and females
- Weight at study initiation (g): males: 211.1-228.6; females: 196.3-209.2
- Housing: in groups of 5 in Makrolon type-4 cages
- Diet: pelleted standard Kliba 3433, batch no 38/98, rat maintenance diet (Kliba Mühlen AG, CH-4303 Kaiseraugst ad libitum
- Water: community tap water from Füllinsdorf ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21
- Humidity (%): 50-82
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Inhalation exposure system:
The animals were confined separately in restraint tubes which were positioned radially around the flow-past, nose-only exposure chambers
The design of this chamber is based upon the fluid dynamic modelling of the test atmosphere flow. It ensures a uniform test item distribution, provides a constant stream of 'fresh' test item to each animal, and precluses re-breathing the exhaled air.
Test atmosphere generation:
The test item was generated using a rotating brush aerosol generator (CR3020, CR equipements, SA, CH-1295 Tannay, Switserland)connected to a micronising jet mill.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 5.371 mg/l air
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
mortality/viability: once daily during the acclimatisation phase, once before exposure on the day of exposure (test day1), once per hour during exposure, once after exposure on test day 1, and twice daily during the remainder of the observation period
body weights: recorded on test datys 1 (before exposure), 4, 8 and 15 (day of necroscopy) using a Mettler PM 4000 balance
clinical signs: once per hour during exposure (only grosly abnormal signs, as the animals were in restraint tubes), once after exposure on test day 1, and once daily thereafter - Statistics:
- the LOGIT-Model was not used as only one group was exposed and there were no deaths
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.371 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- No spontaneous deaths occured
- Clinical signs:
- other: No clinical signs during the 15 day observation period
- Body weight:
- A slight, transient loss in mean body weights was evident in male and female animals from test days 1 to 4
- Gross pathology:
- Necroscopy of each animal did not reveal any macroscopical findings
- Other findings:
- none
Any other information on results incl. tables
A relationship of the slight, transient losses in mean body weight with the treatment with test item could not be fully rulled out, although the generated data did not permit any conclusion to what extent this finding was attributable to slight physical stress which may have occured during restraint in the exposure tubes and to what extent to the treatment with test item.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute inhalation toxicity
- Executive summary:
The purpose of this study was to assess the acute inhalation toxicity of PROBE B Wälzoxid B.U.S. Zinkrecycling Freiberg GMBH when administered to rats for a single continuous 4 -hour period, followed by an observation period of 14 days.
This acute 4 -hour inhalation toxicity test according to OECD 403 with 5.371 mg/l air inhalation of Waelz zinc oxide demonstrated that the LC50 for rats was >5.371 mg/l air
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