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EC number: 283-479-0 | CAS number: 84649-98-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinnamomum zeylanicum, Lauraceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- The Comparative Respiratory Irritation Potential of Fourteen Fragrance Raw Materials
- Author:
- William R. Troy
- Year:
- 1 977
- Bibliographic source:
- Thesis
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Less observation time points: Not at 1h after exposure, nor at 14 and 21 days for reversibility effects Extra observation time point at 4 days. Grading of reactions is similar, but with different calculation method.
- GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- Eugenol
- EC Number:
- 202-589-1
- EC Name:
- Eugenol
- Cas Number:
- 97-53-0
- Molecular formula:
- C10H12O2
- IUPAC Name:
- 4-allyl-2-methoxyphenol
- Test material form:
- liquid
1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Peter J. flinn Rabbitry; Albany, New York
- Housing: individually in stainless steel cages having a wire mesh floor 16"x 19". The rack was of self-flushing variety.
- Diet: Tekklad Rabbit Feed ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20
- Humidity (%): 50
- Photoperiod (hrs dark / hrs light): lighting cycle (probably 12 / 12)
IN-LIFE DATES: From: To:
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1mL
- Observation period (in vivo):
- Seven days.
Time points on 24h, 48h, 72h, four days and seven days. - Number of animals or in vitro replicates:
- six female rabbits
- Details on study design:
- SCORING SYSTEM:
(1) Cornea
A. Opacity degree of density (area most dense taken for reading)
No opacity 0
Scattered or diffuse area, details of iris clearly visible 1
Easily dicernible translucent areas, details of iris slightly obscured 2
Opalescent areas, no details of iris visible, size of pupil barely discernible 3
Opaque, iris invisible 4
B. Area of cornea involved
One quarter (or less) but not zero 1
Greaters than one quarter, but less than half 2
Greater than half but less than three quarters 3
Greater than three quarters, up to whole area 4
A x B x 5 Total maximum = 80
(2) Iris
A. Values
Normal 0
Folds above normal, congestion, swelling, circumcorneal injection (any or all of these or combination of any thereof) iris still reacting to light (sluggish reaction is positive) 1
No reaction to light, hemorrhage, gross destruction (any or all of these 2
A x 5 Total maximum = 10
(3) Conjunctivae
A. Redness (refers to palpebral and bulbar conjunctivae excluding cornea and iris)
Vessels normal 0
Vessels definitely injected above normal 1
More diffuse, deeper crimson red, individual vessels noit easily discernible 2
Diffuse beefy red 3
B. Chemosis
No swelling 0
Any swelling above normal (including nictitating membrane) 1
Obvious swelling with partial eversion of lids 2
Swelling with lids about half closed 3
Swelling with lids about half closed to completely closed 4
C. Discharge
No discharge 0
Any amount different from normal (does not include small amount abserved in inner canthus of normal animals) 1
Discharge with moistening of the lids and hairs just adjacent to lids 2
Discharge with moistening of the lids and hairs, and considerable area around the eye 3
(A + B + C) x 2 Total maximum = 20
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 24 h
- Score:
- 54
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 48 h
- Score:
- 27
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 72 h
- Score:
- 20
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: 4d
- Score:
- 14
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- 7 d
- Score:
- 3
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The substance is an eye irritant in the eye irritation test (OECD guideline 405). Based on these results, the test substance needs to be classified in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Executive summary:
The potential for eye irritation following exposure to eugenol was assessed in 6 female rabbits (0.1 mL of undiluted eugenol). Observations were carried out at regular intervals over 7 days following exposure. Eugenol appeared to affect the rabbit eyes 1 day following application; however, the effects were reversible as the eye irritation grades decreased over the 7-day observation period.
This eye irritation information for eugenol is based on the standard Draize scale which has an overall score based on a 110 point rating scale. This rating scale is not directly compatible with Regulation (EC) No 1272/2008, Annex I section 3.3 classification criteria. However, based on guidance from various agencies, eugenol appears to be severely irritating in the first 24 hours post-exposure, moderately to mildly irritating after 24 and 72 hours post-exposure, and practically non-irritating after 7 days post-exposure.
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